[cyclohexyl-(2-{4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester

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Chemical Name:[cyclohexyl-(2-{4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester
CAS No.:550377-03-2
Molecular Formula:C₃₀H₄₁Cl₂N₅O₄
Molecular Weight:606.593
Hs Code.:

[cyclohexyl-(2-{4-[5-(2,3-dichloro-phenyl)-2-methyl-2<i>H</i>-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-methyl]-carbamic acid <i>tert</i>-butyl ester

Synonyms:[cyclohexyl-(2-{4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester

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Chemical Property of [cyclohexyl-(2-{4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester

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Technology Process of [cyclohexyl-(2-{4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester

There total 8 articles about [cyclohexyl-(2-{4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidine; hydrochloride

: 550377-02-1
(R)-(2-tert-butoxycarbonylamino-2-cyclohexyl-acetylamino)acetic acid pentafluorophenyl ester

: 550377-03-2
[cyclohexyl-(2-{4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm049967u

Reference yield:

: 2905-54-6
2,3-Dichlorobenzoic acid methyl ester

: 550377-03-2
[cyclohexyl-(2-{4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium bis(trimethylsilyl)amide / 1,2-dimethoxy-ethane / -78 - 20 °C

1.2: 48 percent / 1,2-dimethoxy-ethane / Heating

2.1: 26 percent / methanol / 1 h / 50 °C

3.1: HCl / CH₂Cl₂; dioxane / 2 h / 20 °C

4.1: triethylamine / CH₂Cl₂ / 20 °C

With hydrogenchloride; triethylamine; lithium hexamethyldisilazane; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jm049967u

Reference yield:

: 70491-05-3
(2R)-[(tert-butoxycarbonyl)-amino](cyclohexyl)ethanoic acid

: 550377-03-2
[cyclohexyl-(2-{4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: EDC; HOBt monohydrate; triethylamine / CH₂Cl₂ / 20 °C

2: aq. LiOH / tetrahydrofuran / 20 °C

3: pyridine / tetrahydrofuran / 2 h / 20 °C

4: triethylamine / CH₂Cl₂ / 20 °C

With pyridine; lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm049967u