3-hydroxy-2-(hydroxymethyl)-2-methylpropyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

Base Information

Chemical Name:3-hydroxy-2-(hydroxymethyl)-2-methylpropyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate
CAS No.:1268385-09-6
Molecular Formula:C₃₁H₂₆F₅N₅O₅
Molecular Weight:643.57
Hs Code.:

3-hydroxy-2-(hydroxymethyl)-2-methylpropyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

Synonyms:3-hydroxy-2-(hydroxymethyl)-2-methylpropyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

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Chemical Property of 3-hydroxy-2-(hydroxymethyl)-2-methylpropyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

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Technology Process of 3-hydroxy-2-(hydroxymethyl)-2-methylpropyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

There total 12 articles about 3-hydroxy-2-(hydroxymethyl)-2-methylpropyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 77-85-0
2-(hydroxymethyl)-2-methylpropane-1,3-diol

: 1268385-05-2
4-(Dimethylamino)butyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

: 1268385-09-6
3-hydroxy-2-(hydroxymethyl)-2-methylpropyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 30 ℃; for 5h;

Reference yield:

: 1268385-47-2
2-{3-[4-bromo-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-ethanol

: 1268385-09-6
3-hydroxy-2-(hydroxymethyl)-2-methylpropyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; water / 55 °C / Inert atmosphere

2.1: periodic acid / acetonitrile / 2 - 20 °C

2.2: 2 - 20 °C

3.1: methanol / 65 °C

4.1: lithium carbonate / N,N-dimethyl-formamide / 0 °C

5.1: hydrogen bromide / ethyl acetate; acetic acid / 0 - 20 °C

6.1: triethylamine / N,N-dimethyl-formamide / 5 h / 30 °C

With hydrogen bromide; lithium carbonate; periodic acid; triethylamine; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In methanol; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 7657-09-2
1,4-dibromo-2-(trifluoromethyl)benzene

: 1268385-09-6
3-hydroxy-2-(hydroxymethyl)-2-methylpropyl {3-[4-cyclopropyl-2-(trifluoromethyl)phenyl]-5-isoxazolyl}[2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / hexane; tert-butyl methyl ether / 0 - 25 °C

1.2: 0 °C

1.3: 50 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide

2.2: 3 h / 50 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; water / 55 °C / Inert atmosphere

4.1: periodic acid / acetonitrile / 2 - 20 °C

4.2: 2 - 20 °C

5.1: methanol / 65 °C

6.1: lithium carbonate / N,N-dimethyl-formamide / 0 °C

7.1: hydrogen bromide / ethyl acetate; acetic acid / 0 - 20 °C

8.1: triethylamine / N,N-dimethyl-formamide / 5 h / 30 °C

With N-chloro-succinimide; n-butyllithium; hydrogen bromide; lithium carbonate; periodic acid; triethylamine; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In methanol; hexane; tert-butyl methyl ether; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;