{1-[6-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{1-[6-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester
CAS No.:350697-55-1
Molecular Formula:C₃₃H₄₁N₅O₇
Molecular Weight:619.718
Hs Code.:

{1-[6-(2-<i>tert</i>-butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid <i>tert</i>-butyl ester

Synonyms:{1-[6-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

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Chemical Property of {1-[6-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

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Technology Process of {1-[6-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

There total 6 articles about {1-[6-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 244089-24-5
4-Benzyloxy-2,6-bis(N-tert-butoxycarbonyl-L-phenylalaninylamino)pyridine

: 350697-55-1
{1-[6-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With ammonium formate; 10percent Pd/C; In methanol; for 0.5h; Heating;
DOI:10.1002/1521-3765(20010504)7:9<1889::AID-CHEM1889>3.0.CO;2-7

Reference yield:

: 18986-54-4
4?benzyloxy?2,6?diaminopyridine

: 350697-55-1
{1-[6-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 91 percent / 4-DMAP / CH₂Cl₂ / 24 h / 20 °C

2.1: 99 percent / H₂ / 10percent Pd/C / ethanol; CH₂Cl₂ / 18 h / 20 °C

3.1: 99 percent / K₂CO₃; TBAB / dimethylsulfoxide / 18 h / 20 °C

4.1: aq. TFA / CH₂Cl₂

5.1: N,O-bis(trimethylsilylacetamide) / acetonitrile / 2 h / 20 °C

5.2: TBAF / acetonitrile / 12 h / 20 °C

6.1: 94 percent / ammonium formate / 10percent Pd/C / methanol / 0.5 h / Heating

With dmap; N,O-bis-(trimethylsilyl)-acetamide; tetrabutylammomium bromide; hydrogen; ammonium formate; potassium carbonate; trifluoroacetic acid; 10percent Pd/C; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1002/1521-3765(20010504)7:9<1889::AID-CHEM1889>3.0.CO;2-7

Reference yield:

: 416852-99-8
(2,6-diamino-pyridin-4-yloxy)-acetic acid benzyl ester

: 350697-55-1
{1-[6-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,O-bis(trimethylsilylacetamide) / acetonitrile / 2 h / 20 °C

1.2: TBAF / acetonitrile / 12 h / 20 °C

2.1: 94 percent / ammonium formate / 10percent Pd/C / methanol / 0.5 h / Heating

With N,O-bis-(trimethylsilyl)-acetamide; ammonium formate; 10percent Pd/C; In methanol; acetonitrile;
DOI:10.1002/1521-3765(20010504)7:9<1889::AID-CHEM1889>3.0.CO;2-7