(3S,4R)-3-<(1R)-1-triethylsilyloxyethyl>-4-<(1S)-1-(2-p-methoxybenzyloxyethyl)-2-oxo-3-acetoxypropyl>-1-(diphenylmethoxycarbonyl-triphenylphosphoranylidenemethyl)-2-azetidinone

Base Information

Chemical Name:(3S,4R)-3-<(1R)-1-triethylsilyloxyethyl>-4-<(1S)-1-(2-p-methoxybenzyloxyethyl)-2-oxo-3-acetoxypropyl>-1-(diphenylmethoxycarbonyl-triphenylphosphoranylidenemethyl)-2-azetidinone
CAS No.:220430-16-0
Molecular Formula:C₅₉H₆₆NO₉PSi
Molecular Weight:992.234
Hs Code.:

(3S,4R)-3-<(1R)-1-triethylsilyloxyethyl>-4-<(1S)-1-(2-p-methoxybenzyloxyethyl)-2-oxo-3-acetoxypropyl>-1-(diphenylmethoxycarbonyl-triphenylphosphoranylidenemethyl)-2-azetidinone

Synonyms:(3S,4R)-3-<(1R)-1-triethylsilyloxyethyl>-4-<(1S)-1-(2-p-methoxybenzyloxyethyl)-2-oxo-3-acetoxypropyl>-1-(diphenylmethoxycarbonyl-triphenylphosphoranylidenemethyl)-2-azetidinone

Suppliers and Price of (3S,4R)-3-<(1R)-1-triethylsilyloxyethyl>-4-<(1S)-1-(2-p-methoxybenzyloxyethyl)-2-oxo-3-acetoxypropyl>-1-(diphenylmethoxycarbonyl-triphenylphosphoranylidenemethyl)-2-azetidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4R)-3-<(1R)-1-triethylsilyloxyethyl>-4-<(1S)-1-(2-p-methoxybenzyloxyethyl)-2-oxo-3-acetoxypropyl>-1-(diphenylmethoxycarbonyl-triphenylphosphoranylidenemethyl)-2-azetidinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4R)-3-<(1R)-1-triethylsilyloxyethyl>-4-<(1S)-1-(2-p-methoxybenzyloxyethyl)-2-oxo-3-acetoxypropyl>-1-(diphenylmethoxycarbonyl-triphenylphosphoranylidenemethyl)-2-azetidinone

There total 13 articles about (3S,4R)-3-<(1R)-1-triethylsilyloxyethyl>-4-<(1S)-1-(2-p-methoxybenzyloxyethyl)-2-oxo-3-acetoxypropyl>-1-(diphenylmethoxycarbonyl-triphenylphosphoranylidenemethyl)-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 220430-16-0
(3S,4R)-3-<(1R)-1-triethylsilyloxyethyl>-4-<(1S)-1-(2-p-methoxybenzyloxyethyl)-2-oxo-3-acetoxypropyl>-1-(diphenylmethoxycarbonyl-triphenylphosphoranylidenemethyl)-2-azetidinone

Guidance literature:: Multi-step reaction with 13 steps

1: NaH / dimethylformamide / 1 h / Ambient temperature

2: O₃; dimethyl sulfide / CH₂Cl₂; methanol / 1.5 h / -78 °C

3: 60 percent / 3-quinuclidinol / neat (no solvent) / 48 h / Ambient temperature

4: 76 percent / NBS, dimethylsulfide / CH₂Cl₂; toluene / 15 h / Ambient temperature

5: 92 percent / zinc dust / dimethylformamide / 2 h / Ambient temperature

6: DIBAL-H / toluene; methanol / -78 - 0 °C

7: triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

8: conc. HCl, acetic acid / acetonitrile / 0.5 h / 0 °C

9: imidazole / dimethylformamide / 0.33 h / 0 °C

10: 1.) O₃; 2.) dimethylsulfide / 1.) CH₂Cl₂, CH₃OH, -78 deg C, 40 min

11: 87 percent / 4 Angstroem molecular sieves / toluene / 3 h / Heating

12: 2,6-lutidine, thionyl chloride / tetrahydrofuran / 0.5 h / -40 °C

13: 2,6-lutidine, NaBr / tetrahydrofuran / 1 h / Ambient temperature

With 1H-imidazole; 2,6-dimethylpyridine; hydrogenchloride; N-Bromosuccinimide; thionyl chloride; dimethylsulfide; 4 A molecular sieve; sodium hydride; diisobutylaluminium hydride; ozone; acetic acid; triethylamine; 3-quinuclidinol; sodium bromide; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.3987/COM-98-8302

Reference yield:

: 128461-65-4
3-(p-methoxybenzyloxy)propanal

: 220430-16-0
(3S,4R)-3-<(1R)-1-triethylsilyloxyethyl>-4-<(1S)-1-(2-p-methoxybenzyloxyethyl)-2-oxo-3-acetoxypropyl>-1-(diphenylmethoxycarbonyl-triphenylphosphoranylidenemethyl)-2-azetidinone

Guidance literature:: Multi-step reaction with 11 steps

1: 60 percent / 3-quinuclidinol / neat (no solvent) / 48 h / Ambient temperature

2: 76 percent / NBS, dimethylsulfide / CH₂Cl₂; toluene / 15 h / Ambient temperature

3: 92 percent / zinc dust / dimethylformamide / 2 h / Ambient temperature

4: DIBAL-H / toluene; methanol / -78 - 0 °C

5: triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

6: conc. HCl, acetic acid / acetonitrile / 0.5 h / 0 °C

7: imidazole / dimethylformamide / 0.33 h / 0 °C

8: 1.) O₃; 2.) dimethylsulfide / 1.) CH₂Cl₂, CH₃OH, -78 deg C, 40 min

9: 87 percent / 4 Angstroem molecular sieves / toluene / 3 h / Heating

10: 2,6-lutidine, thionyl chloride / tetrahydrofuran / 0.5 h / -40 °C

11: 2,6-lutidine, NaBr / tetrahydrofuran / 1 h / Ambient temperature

With 1H-imidazole; 2,6-dimethylpyridine; hydrogenchloride; N-Bromosuccinimide; thionyl chloride; dimethylsulfide; 4 A molecular sieve; diisobutylaluminium hydride; ozone; acetic acid; triethylamine; 3-quinuclidinol; sodium bromide; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.3987/COM-98-8302

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 220430-16-0
(3S,4R)-3-<(1R)-1-triethylsilyloxyethyl>-4-<(1S)-1-(2-p-methoxybenzyloxyethyl)-2-oxo-3-acetoxypropyl>-1-(diphenylmethoxycarbonyl-triphenylphosphoranylidenemethyl)-2-azetidinone

Guidance literature:: Multi-step reaction with 14 steps

1: aq. HBr / 0.5 h / Ambient temperature

2: NaH / dimethylformamide / 1 h / Ambient temperature

3: O₃; dimethyl sulfide / CH₂Cl₂; methanol / 1.5 h / -78 °C

4: 60 percent / 3-quinuclidinol / neat (no solvent) / 48 h / Ambient temperature

5: 76 percent / NBS, dimethylsulfide / CH₂Cl₂; toluene / 15 h / Ambient temperature

6: 92 percent / zinc dust / dimethylformamide / 2 h / Ambient temperature

7: DIBAL-H / toluene; methanol / -78 - 0 °C

8: triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

9: conc. HCl, acetic acid / acetonitrile / 0.5 h / 0 °C

10: imidazole / dimethylformamide / 0.33 h / 0 °C

11: 1.) O₃; 2.) dimethylsulfide / 1.) CH₂Cl₂, CH₃OH, -78 deg C, 40 min

12: 87 percent / 4 Angstroem molecular sieves / toluene / 3 h / Heating

13: 2,6-lutidine, thionyl chloride / tetrahydrofuran / 0.5 h / -40 °C

14: 2,6-lutidine, NaBr / tetrahydrofuran / 1 h / Ambient temperature

With 1H-imidazole; 2,6-dimethylpyridine; hydrogenchloride; N-Bromosuccinimide; thionyl chloride; dimethylsulfide; 4 A molecular sieve; hydrogen bromide; sodium hydride; diisobutylaluminium hydride; ozone; acetic acid; triethylamine; 3-quinuclidinol; sodium bromide; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.3987/COM-98-8302