3-(3-chloro-phenyl)-5-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-7-methoxy-benzo[c]isoxazole

Base Information

• Chemical Name: 3-(3-chloro-phenyl)-5-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-7-methoxy-benzo[c]isoxazole
• CAS No.: 213389-45-8
• Molecular Formula: C₂₃H₁₇Cl₂NO₄
• Molecular Weight: 442.298

Synonyms:3-(3-chloro-phenyl)-5-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-7-methoxy-benzo[c]isoxazole

Chemical Property of 3-(3-chloro-phenyl)-5-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-7-methoxy-benzo[c]isoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-(3-chloro-phenyl)-5-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-7-methoxy-benzo[c]isoxazole

There total 5 articles about 3-(3-chloro-phenyl)-5-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-7-methoxy-benzo[c]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

3-chloro-benzonitrile (766-84-7) + 2-(4-chloro-phenyl)-2-(3-methoxy-4-nitro-phenyl)-[1,3]dioxolane (213389-44-7) → 3-(3-chloro-phenyl)-5-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-7-methoxy-benzo[c]isoxazole (213389-45-8)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1016/S0960-894X(03)00180-X

Reference yield:

2-Nitroanisole (91-23-6) → 3-(3-chloro-phenyl)-5-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-7-methoxy-benzo[c]isoxazole (213389-45-8)

Guidance literature:

Multi-step reaction with 4 steps

1: AlCl₃ / CH₂Cl₂

2: K₂CO₃ / acetonitrile

3: APTS / toluene

4: 27 percent / NaOH / methanol

With sodium hydroxide; aluminium trichloride; potassium carbonate; 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt; In methanol; dichloromethane; toluene; acetonitrile; 1: Friedel-Crafts reaction;

DOI:10.1016/S0960-894X(03)00180-X

Reference yield:

4-chloro-benzoyl chloride (122-01-0) → 3-(3-chloro-phenyl)-5-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-7-methoxy-benzo[c]isoxazole (213389-45-8)

Guidance literature:

Multi-step reaction with 4 steps

1: AlCl₃ / CH₂Cl₂

2: K₂CO₃ / acetonitrile

3: APTS / toluene

4: 27 percent / NaOH / methanol

With sodium hydroxide; aluminium trichloride; potassium carbonate; 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt; In methanol; dichloromethane; toluene; acetonitrile; 1: Friedel-Crafts reaction;

DOI:10.1016/S0960-894X(03)00180-X

upstream raw materials:

3-chloro-benzonitrile

2-(4-chloro-phenyl)-2-(3-methoxy-4-nitro-phenyl)-[1,3]dioxolane

2-Nitroanisole

4-chloro-benzoyl chloride

Downstream raw materials:

6-(3-chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2,3-dihydro-1-oxa-3a-aza-phenalen-4-one

4-(3-chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-8-hydroxy-1H-quinolin-2-one

4-(3-chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-8-methoxy-1H-quinolin-2-one

N-[4-(4-chloro-benzoyl)-2-(3-chloro-benzoyl)-6-methoxy-phenyl]-acetamide

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