4-[5-(3,5-dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-benzylamine

Base Information

Chemical Name:4-[5-(3,5-dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-benzylamine
CAS No.:1330021-35-6
Molecular Formula:C₁₉H₁₇Cl₂F₃N₂O
Molecular Weight:417.258
Hs Code.:

Synonyms:4-[5-(3,5-dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-benzylamine

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Chemical Property of 4-[5-(3,5-dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-benzylamine

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Technology Process of 4-[5-(3,5-dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-benzylamine

There total 9 articles about 4-[5-(3,5-dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-benzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1330021-33-4
2-{4-[5-(3,5-Dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-benzyl}-isoindole-1,3-dione

: 1330021-35-6
4-[5-(3,5-dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-benzylamine

Guidance literature:: With hydrazine hydrate; In ethanol; for 2h; Reflux;

Reference yield:

: 3114-08-7
2-bromo-1-(4-bromo-3-methylphenyl)ethan-1-one

: 1330021-35-6
4-[5-(3,5-dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-benzylamine

Guidance literature:: Multi-step reaction with 9 steps

1: dichloromethane / 18 h / 20 °C

2: sodium hydrogencarbonate / dichloromethane; water

3: toluene / 3 h / Reflux

4: triethylamine / bis-triphenylphosphine-palladium(II) chloride / 20 h / 120 °C / 45004.5 Torr

5: triethylamine / ethanol / 20 h / Reflux

6: sodium tetrahydroborate; methanol / tetrahydrofuran / 60 °C

7: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

8: sodium iodide / N,N-dimethyl-formamide / 20 °C

9: hydrazine hydrate / ethanol / 2 h / Reflux

With methanol; sodium tetrahydroborate; thionyl chloride; sodium hydrogencarbonate; hydrazine hydrate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl-formamide; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 943437-03-4
1-(4-bromo-3-methylphenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-en-1-one

: 1330021-35-6
4-[5-(3,5-dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-benzylamine

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / 20 h / 120 °C / 45004.5 Torr

2: triethylamine / ethanol / 20 h / Reflux

3: sodium tetrahydroborate; methanol / tetrahydrofuran / 60 °C

4: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

5: sodium iodide / N,N-dimethyl-formamide / 20 °C

6: hydrazine hydrate / ethanol / 2 h / Reflux

With methanol; sodium tetrahydroborate; thionyl chloride; hydrazine hydrate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl-formamide; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;