ethyl (E)-3-[(2S,3R,4R)-4-(2,4-dimethoxyphenyl)-4-hydroxy-5-oxo-1,2-diphenylpyrrolidin-3-yl]acrylate

Base Information

Chemical Name:ethyl (E)-3-[(2S,3R,4R)-4-(2,4-dimethoxyphenyl)-4-hydroxy-5-oxo-1,2-diphenylpyrrolidin-3-yl]acrylate
CAS No.:1619932-99-8
Molecular Formula:C₂₉H₂₉NO₆
Molecular Weight:487.552
Hs Code.:

Synonyms:ethyl (E)-3-[(2S,3R,4R)-4-(2,4-dimethoxyphenyl)-4-hydroxy-5-oxo-1,2-diphenylpyrrolidin-3-yl]acrylate

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Chemical Property of ethyl (E)-3-[(2S,3R,4R)-4-(2,4-dimethoxyphenyl)-4-hydroxy-5-oxo-1,2-diphenylpyrrolidin-3-yl]acrylate

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Technology Process of ethyl (E)-3-[(2S,3R,4R)-4-(2,4-dimethoxyphenyl)-4-hydroxy-5-oxo-1,2-diphenylpyrrolidin-3-yl]acrylate

There total 6 articles about ethyl (E)-3-[(2S,3R,4R)-4-(2,4-dimethoxyphenyl)-4-hydroxy-5-oxo-1,2-diphenylpyrrolidin-3-yl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₃NO₅

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 1619932-99-8
ethyl (E)-3-[(2S,3R,4R)-4-(2,4-dimethoxyphenyl)-4-hydroxy-5-oxo-1,2-diphenylpyrrolidin-3-yl]acrylate

Guidance literature:: In ethanol; at 20 ℃; for 16h;
DOI:10.1055/s-0033-1340565

Reference yield:

: 6592-19-4
(2,4-dimethoxyphenyl)-glyoxalic acid ethyl ester

: 1619932-99-8
ethyl (E)-3-[(2S,3R,4R)-4-(2,4-dimethoxyphenyl)-4-hydroxy-5-oxo-1,2-diphenylpyrrolidin-3-yl]acrylate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / ethanol; water / 0.25 h / 20 °C

2: thionyl chloride / N,N-dimethyl acetamide / 1 h / -15 °C

3: N,N-dimethyl acetamide / 3 h / -10 - 0 °C

4: (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine / ethanol / 7 h / 20 °C

5: ethanol / 16 h / 20 °C

With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; thionyl chloride; sodium hydroxide; In ethanol; N,N-dimethyl acetamide; water; 5: |Wittig Olefination;
DOI:10.1055/s-0033-1340565

Reference yield:

: 26767-17-9
2-(2,4-dimethoxybenzene)-2-oxoacetic acid

: 1619932-99-8
ethyl (E)-3-[(2S,3R,4R)-4-(2,4-dimethoxyphenyl)-4-hydroxy-5-oxo-1,2-diphenylpyrrolidin-3-yl]acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / N,N-dimethyl acetamide / 1 h / -15 °C

2: N,N-dimethyl acetamide / 3 h / -10 - 0 °C

3: (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine / ethanol / 7 h / 20 °C

4: ethanol / 16 h / 20 °C

With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; thionyl chloride; In ethanol; N,N-dimethyl acetamide; 4: |Wittig Olefination;
DOI:10.1055/s-0033-1340565