6592-19-4

Basic information

• Product Name: ETHYL 2,4-DIMETHOXYBENZOYLFORMATE
• Synonyms: ETHYL 2,4-DIMETHOXYBENZOYLFORMATE;Ethyl 2-(2,4-dimethoxyphenyl)-2-oxoacetate
• CAS NO: 6592-19-4
• Molecular Formula: C₁₂H₁₄O₅
• Molecular Weight: 238.24
• Mol File: 6592-19-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 365.8°C at 760 mmHg
• Flash Point: 162.3°C
• Appearance: /
• Density: 1.159g/cm³
• Vapor Pressure: 1.53E-05mmHg at 25°C
• Refractive Index: 1.502
• CAS DataBase Reference: ETHYL 2,4-DIMETHOXYBENZOYLFORMATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2,4-DIMETHOXYBENZOYLFORMATE(6592-19-4)
• EPA Substance Registry System: ETHYL 2,4-DIMETHOXYBENZOYLFORMATE(6592-19-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 6592-19-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H14O5/c1-4-17-12(14)11(13)9-6-5-8(15-2)7-10(9)16-3/h5-7H,4H2,1-3H3

Upstream product

• 4755-77-5 Ethyl oxalyl chloride 
• 151-10-0 1,3-Dimethoxybenzene 
• 17715-69-4 1-Bromo-2,4-dimethoxybenzene 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 1285212-71-6 2-(2,4-dimethoxyphenyl)-2-oxo-N-phenylacetamide 
• 26767-17-9 2-(2,4-dimethoxybenzene)-2-oxoacetic acid 
• 1619932-99-8 ethyl (E)-3-[(2S,3R,4R)-4-(2,4-dimethoxyphenyl)-4-hydroxy-5-oxo-1,2-diphenylpyrrolidin-3-yl]acrylate 
• 1281223-21-9 ethyl (2,4-dimethoxyphenyl)(difluoro)acetate 
• 35031-35-7 (5-bromo-2,4-dimethoxy-phenyl)-glyoxylic acid 
• 131391-99-6 3-(2,4-dihydroxyphenyl) coumarin 
• 6592-00-3 ethyl (+)-2-hydroxy-(2',4'-dimethoxyphenyl)acetate 
• 6592-00-3 ethyl (-)-2-hydroxy-(2',4'-dimethoxyphenyl)acetate 
• 131391-98-5 ethyl 2-methoxy-(α-2,4-dimethoxyphenyl)cinnamate 
• 35031-34-6 5-Brom-2,4-dimethoxyphenylglyoxylsaeure-ethylester 

Relevant articles and documents

A short route to access oxaspiro[: N,3,3]propellanes

Novel access to oxaspiro[n,3,3]propellanes has been developed from bicyclic lactones directly prepared by a photochemical hydroxymethylation or alternatively by a three-step sequence. Thanks to the presence of additional hydroxy- and propargylic groups, a second cyclization catalyzed by silver or bismuth salts, led to the propellane structure which was finally transformed into spiranic derivatives by a Simmons-Smith reaction or condensation with α-ketoesters.

Organocatalytic asymmetric synthesis of functionalized 1,3,5- triarylpyrrolidin-2-ones via an aza-Michael/aldol domino reaction

The organocatalytic asymmetric synthesis of functionalized 1,3,5-triarylpyrrolidin-2-ones bearing three contiguous stereocenters through an aza-Michael/aldol domino reaction of α-ketoamides with α,β-unsaturated aldehydes is described. The domino products

Asymmetric hydrogenation of α-keto acid derivatives by rhodium-{amidophosphine-phosphinite} catalysts

The enantioselective hydrogenation of several α-keto esters (3a-f, 5a-j), α-keto amides (7a-e) and isatine derivatives (9a-d) with a set of four representative neutral homogeneous rhodium-amidophosphine-phosphinite catalysts has been investigated. Trifluoroacetate-Rh-AMPP catalytic precursors promoted the rapid, efficient synthesis of aliphatic α-hydroxy esters 4a-f in moderate to high enantioselectivities (66-95% eel, in contrast to most aromatic α-hydroxy esters 6a-j (8-81% eel. Best enantioselectivities for α-hydroxy amides 8a-e (85-95% eel and dioxindoIes 10a-d (80-94% eel were obtained with chloro-Rh-AMPP precursors. It is proposed that, contrary to α-keto amides, α-keto esters do not chelate onto the rhodium center and that, in such circumstances, the asymmetric induction is mainly controlled by the steric hindrance around the C=O function.