2-(4-DifluoroMethoxy-3-fluorophenyl)-4,4,5,5-tetraMethyl -[1,3,2]dioxaborolane

Base Information

Chemical Name:2-(4-DifluoroMethoxy-3-fluorophenyl)-4,4,5,5-tetraMethyl -[1,3,2]dioxaborolane
CAS No.:1162262-35-2
Molecular Formula:C₁₃H₁₆BF₃O₃
Molecular Weight:288.074
Hs Code.:
Mol file:1162262-35-2.mol

Synonyms:2-(4-(difluoromethoxy)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Suppliers and Price of 2-(4-DifluoroMethoxy-3-fluorophenyl)-4,4,5,5-tetraMethyl -[1,3,2]dioxaborolane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(4-Difluoromethoxy-3-fluoro-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
50mg
$ 150.00

Crysdot
2-(4-(Difluoromethoxy)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 95+%
5g
$ 930.00

Crysdot
2-(4-(Difluoromethoxy)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 95+%
1g
$ 310.00

Chemenu
2-(4-(Difluoromethoxy)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 95+%
250mg
$ 114.00

Chemenu
2-(4-(Difluoromethoxy)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 95+%
1g
$ 310.00

Alichem
2-(4-(Difluoromethoxy)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
5g
$ 967.20

AK Scientific
2-[4-(Difluoromethoxy)-3-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
100mg
$ 262.00

Total 5 raw suppliers

Chemical Property of 2-(4-DifluoroMethoxy-3-fluorophenyl)-4,4,5,5-tetraMethyl -[1,3,2]dioxaborolane

Chemical Property:

Boiling Point:327.2±42.0 °C(Predicted)
Density:1.18±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Difluoromethoxy-3-fluoro-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 2-(4-Difluoromethoxy-3-fluoro-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (cas# 1162262-35-2) is used as a reagent in the preparation of imidazopyrazine derivatives as antibacterials.

Technology Process of 2-(4-DifluoroMethoxy-3-fluorophenyl)-4,4,5,5-tetraMethyl -[1,3,2]dioxaborolane

There total 3 articles about 2-(4-DifluoroMethoxy-3-fluorophenyl)-4,4,5,5-tetraMethyl -[1,3,2]dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1162262-35-2
2-(4-(difluoromethoxy)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:

Reference yield: 58.0%

: 147992-27-6
4-bromo-1-(difluoromethoxy)-2-fluoro-benzene

: 73183-34-3
bis(pinacol)diborane

: 1162262-35-2
2-(4-(difluoromethoxy)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; In 1,4-dioxane; for 16h; Sealed tube; Heating;
DOI:10.1021/acsmedchemlett.7b00317

Reference yield:

: 2105-94-4
4-bromo-2-fluorophenol

: 1162262-35-2
2-(4-(difluoromethoxy)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / N,N-dimethyl-formamide / 18.5 h / 100 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 21 h / 90 °C / Inert atmosphere

With potassium acetate; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; N,N-dimethyl-formamide;