N-[(1-benzyloxycarbonylamino-2-methyl)methoxyphosphinyl]valine

Base Information

• Chemical Name: N-[(1-benzyloxycarbonylamino-2-methyl)methoxyphosphinyl]valine
• CAS No.: 1346551-18-5
• Molecular Formula: C₁₇H₂₇N₂O₆P
• Molecular Weight: 386.385
• Mol file: 1346551-18-5.mol

Synonyms:N-[(1-benzyloxycarbonylamino-2-methyl)methoxyphosphinyl]valine

Chemical Property of N-[(1-benzyloxycarbonylamino-2-methyl)methoxyphosphinyl]valine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(1-benzyloxycarbonylamino-2-methyl)methoxyphosphinyl]valine

There total 5 articles about N-[(1-benzyloxycarbonylamino-2-methyl)methoxyphosphinyl]valine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-valine methylester hydrochloride (6306-52-1) + C11H15ClNO4P (107072-65-1) → N-[(1-benzyloxycarbonylamino-2-methyl)methoxyphosphinyl]valine (1346551-18-5)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 24h; Cooling with ice;

DOI:10.1016/j.bmcl.2011.09.020

Reference yield:

O-benzyl carbamate (621-84-1) → N-[(1-benzyloxycarbonylamino-2-methyl)methoxyphosphinyl]valine (1346551-18-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: acetic acid / Cooling with ice

1.2: 1 h / 85 °C

2.1: 1,4-dioxane; methanol

3.1: sodium iodide / acetone / 0.08 h / Reflux

4.1: thionyl chloride / dichloromethane / 4 h / 20 °C / Cooling with ice

5.1: triethylamine / chloroform / 24 h / 20 °C / Cooling with ice

With thionyl chloride; acetic acid; triethylamine; sodium iodide; In 1,4-dioxane; methanol; dichloromethane; chloroform; acetone;

DOI:10.1016/j.bmcl.2011.09.020

Reference yield:

methyl hydrogen 1-(benzyloxycarbonylamino)ethyl phosphonate sodium salt (1346551-15-2) → N-[(1-benzyloxycarbonylamino-2-methyl)methoxyphosphinyl]valine (1346551-18-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 4 h / 20 °C / Cooling with ice

2: triethylamine / chloroform / 24 h / 20 °C / Cooling with ice

With thionyl chloride; triethylamine; In dichloromethane; chloroform;

DOI:10.1016/j.bmcl.2011.09.020

upstream raw materials:

methyl hydrogen 1-(benzyloxycarbonylamino)ethyl phosphonate sodium salt

O-benzyl carbamate

diphenyl 1-(phenylmethoxycarbonylamino)ethyl phosphonate

L-valine methylester hydrochloride