(2S,3S)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Base Information

Chemical Name:(2S,3S)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol
CAS No.:135269-83-9
Molecular Formula:C₁₂H₁₃F₂N₃OS
Molecular Weight:285.318
Hs Code.:

Synonyms:(2S,3S)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol

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Chemical Property of (2S,3S)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol

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Technology Process of (2S,3S)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol

There total 6 articles about (2S,3S)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 135270-07-4
(2S,3R)-2-(2,4-difluorophenyl)-3-methyl-2-<(1H-1,2,4-triazol-1-yl)methyl>oxirane

: 135269-83-9
(2S,3S)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Guidance literature:: With Methyl 3-mercaptopropionate; sodium methylate; for 4h; Heating;
DOI:10.1248/cpb.41.1035

Reference yield:

: 127001-03-0
(2S)-2',4'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

: 135269-83-9
(2S,3S)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMSO, RT, 30 min, 2.) DMSO, RT, 2 h

2: 1.) NaH / 1.) DMF, RT, 15 min, 2.) DMF, 80 deg C, 4 h

3: PPTS / ethanol / 4 h / 55 °C

4: Et₃N / ethyl acetate; CH₂Cl₂ / 0.75 h / Ambient temperature

5: NaOMe / methanol / 0.25 h / 0 °C

6: 71 percent / methyl 3-mercaptopropionate, 28percent NaOMe in methanol / 4 h / Heating

With Methyl 3-mercaptopropionate; sodium methylate; pyridinium p-toluenesulfonate; sodium hydride; triethylamine; In methanol; ethanol; dichloromethane; ethyl acetate;
DOI:10.1248/cpb.41.1035

Reference yield:

: 135270-05-2
(2S,3S)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2,3-butanediol

: 135269-83-9
(2S,3S)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / ethyl acetate; CH₂Cl₂ / 0.75 h / Ambient temperature

2: NaOMe / methanol / 0.25 h / 0 °C

3: 71 percent / methyl 3-mercaptopropionate, 28percent NaOMe in methanol / 4 h / Heating

With Methyl 3-mercaptopropionate; sodium methylate; triethylamine; In methanol; dichloromethane; ethyl acetate;
DOI:10.1248/cpb.41.1035