(2S)-2',4'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

Base Information

• Chemical Name: (2S)-2',4'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone
• CAS No.: 127001-03-0
• Molecular Formula: C₁₄H₁₆F₂O₃
• Molecular Weight: 270.276
• Mol file: 127001-03-0.mol

Synonyms:(2S)-2',4'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

Chemical Property of (2S)-2',4'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

Chemical Property:

Purity/Quality:

(2S)-1-(2,4-Difluorophenyl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (2S)-1-(2,4-Difluorophenyl)-2-((tetrahydro-2H-pyran-2-yl)oxy)propan-1-one is a useful intermediate for the preparation of triazoles with antifungal properties.

Technology Process of (2S)-2',4'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

There total 20 articles about (2S)-2',4'-difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,4-dihydro-2H-pyran (110-87-2) + (R)-1-(2,4-difluorophenyl)-2-hydroxypropan-1-one (126918-16-9) → (2R)-2',4'-Difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone (127001-03-0,132563-81-6,138381-87-0,138381-88-1,126918-17-0)

Guidance literature:

With pyridinium p-toluenesulfonate; Ambient temperature;

DOI:10.1016/S0040-4039(00)74391-7

Reference yield: 98.0%

(R)-1-(1 piperidinyl)-2-(2-tetrahydropyranyl)oxy-1-propanone + (2,4-difluorophenyl)magnesium bromide (144025-04-7) → (2R)-2',4'-Difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone (127001-03-0,132563-81-6,138381-87-0,138381-88-1,126918-17-0)

Guidance literature:

In tetrahydrofuran; at -20 - 20 ℃; for 4.25h; Large scale;

Reference yield: 98.0%

(R)-1-(1-azetidinyl)-2-(2-tetrahydropyranyl)oxy-1-propanone + (2,4-difluorophenyl)magnesium bromide (144025-04-7) → (2R)-2',4'-Difluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone (127001-03-0,132563-81-6,138381-87-0,138381-88-1,126918-17-0)

Guidance literature:

In tetrahydrofuran; at -20 - 20 ℃; for 4.25h; Large scale;

upstream raw materials:

3,4-dihydro-2H-pyran

(2S)-2',4'-Difluoro-2-hydroxypropiophenone

2,4-difluorobromobenzene

4-<(2S)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propionyl>morpholine

Downstream raw materials:

(2R,3S)-2-(2,4-Difluoro-phenyl)-1-(isopropoxy-dimethyl-silanyl)-3-(tetrahydro-pyran-2-yloxy)-butan-2-ol

(2S,3R)-2-(2,4-difluorophenyl)-1-(dimethylisopropoxysilyl)-3-(2-tetrahydropyranyloxy)-2-butanol

1-[(2R,3R)-2-(2,4-difluorophenyl)-2,3-dihydroxybutyl]-1H-[1,2,4]triazole methanesulfonate salt

2-[(1R)-1-(3,4,5,6-Tetrahydro-2H-pyran-2-yl)oxyethyl]-2-(2,4-difluorophenyl)oxirane