5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-3H-1,2,4-triazol-3-one

Base Information

Chemical Name:5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-3H-1,2,4-triazol-3-one
CAS No.:170647-85-5
Molecular Formula:C₃₄H₃₉F₄N₅O₅S
Molecular Weight:705.774
Hs Code.:

5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-3H-1,2,4-triazol-3-one

Synonyms:5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-3H-1,2,4-triazol-3-one

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Chemical Property of 5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-3H-1,2,4-triazol-3-one

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Technology Process of 5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-3H-1,2,4-triazol-3-one

There total 9 articles about 5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 627-03-2
3-oxapentanoic acid

: 170647-84-4
2-<5-amino-2-(trifluoromethyl)phenyl>-5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

: 170647-85-5
5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-3H-1,2,4-triazol-3-one

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1021/jm00019a004

Reference yield:

: 51436-99-8
2-fluoro-4-bromotoluene

: 170647-85-5
5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / aq. NaOH, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / ethanol / 4.5 h / 90 °C

2: Br₂ / CCl₄ / Heating; Irradiation

3: 1.) NaH / 1.) DMF, RT, 3.5 h, 2.) DMF, 35 deg C, 24 h

4: 62 percent / KF, CuI, KBr / dimethylformamide / 15 h / 120 °C

5: 91 percent / H₂ / PtO₂ / ethyl acetate; ethanol / 2 h / 1520 Torr

6: 88 percent / BOP, Et₃N / CH₂Cl₂ / Ambient temperature

With potassium fluoride; sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; bromine; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; potassium bromide; platinum(IV) oxide; In tetrachloromethane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00019a004

Reference yield:

: 100367-78-0
(2-bromo-5-nitrophenyl)hydrazine

: 170647-85-5
5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)-3-fluorobiphenyl-4-yl>methyl>-2,4-dihydro-2-<5-<(ethoxyacetyl)amino>-2-(trifluoromethyl)phenyl>-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: 2.) Et₃N / 1.) THF, 65 deg C, 4 h, 2.) THF, 90 deg C, 20 h

2: 1.) NaH / 1.) DMF, RT, 3.5 h, 2.) DMF, 35 deg C, 24 h

3: 62 percent / KF, CuI, KBr / dimethylformamide / 15 h / 120 °C

4: 91 percent / H₂ / PtO₂ / ethyl acetate; ethanol / 2 h / 1520 Torr

5: 88 percent / BOP, Et₃N / CH₂Cl₂ / Ambient temperature

With potassium fluoride; copper(l) iodide; hydrogen; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; potassium bromide; platinum(IV) oxide; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00019a004