(S)-4-(carboxymethyl)-α-<<(1,1-dimethylethoxy)carbonyl>amino>benzenepropanoic acid methylester

Base Information

• Chemical Name: (S)-4-(carboxymethyl)-α-<<(1,1-dimethylethoxy)carbonyl>amino>benzenepropanoic acid methylester
• CAS No.: 123993-28-2
• Molecular Formula: C₁₇H₂₃NO₆
• Molecular Weight: 337.373
• Mol file: 123993-28-2.mol

Synonyms:(S)-4-(carboxymethyl)-α-<<(1,1-dimethylethoxy)carbonyl>amino>benzenepropanoic acid methylester

Chemical Property of (S)-4-(carboxymethyl)-α-<<(1,1-dimethylethoxy)carbonyl>amino>benzenepropanoic acid methylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-(carboxymethyl)-α-<<(1,1-dimethylethoxy)carbonyl>amino>benzenepropanoic acid methylester

There total 2 articles about (S)-4-(carboxymethyl)-α-<<(1,1-dimethylethoxy)carbonyl>amino>benzenepropanoic acid methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(2-propenyl)benzenepropanoic acid methylester (123993-26-0) → (S)-4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)benzoic acid (123993-33-9) + (S)-4-(carboxymethyl)-α-<<(1,1-dimethylethoxy)carbonyl>amino>benzenepropanoic acid methylester (123993-28-2)

Guidance literature:

With sodium periodate; sodium chlorite in NaH₂PO₄-buffer; ruthenium trichloride; Multistep reaction; 1) CCl₄, CH₃CN, water, RT, 1h, 2) tert-butylalcohol, 2-methyl-2-butene, water, 2 h;

DOI:10.1021/jo00290a021

Reference yield:

sodium chlorite (7758-19-2) + sodium dihydrogen phosphate + 2-methyl-but-2-ene (513-35-9) + (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(2-propenyl)benzenepropanoic acid methylester (123993-26-0) → (S)-4-(carboxymethyl)-α-<<(1,1-dimethylethoxy)carbonyl>amino>benzenepropanoic acid methylester (123993-28-2)

Guidance literature:

With sodium thiosulfate; ruthenium (III) chloride hydrate; In tetrachloromethane; dichloromethane; water; acetonitrile; tert-butyl alcohol;

Reference yield: 65.0%

(S)-4-(carboxymethyl)-α-<<(1,1-dimethylethoxy)carbonyl>amino>benzenepropanoic acid methylester (123993-28-2) + N,N-dimethylformamide di-tert-butyl acetal (36805-97-7) → (S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid methylester (123993-30-6)

Guidance literature:

In toluene; at 80 ℃; for 4h;

DOI:10.1021/jo00290a021

upstream raw materials:

(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(2-propenyl)benzenepropanoic acid methylester

sodium chlorite

2-methyl-but-2-ene

Downstream raw materials:

(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid methylester

(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<2-(1,1-dimethylethoxy)-2-oxoethyl>benzenepropanoic acid