(S)-4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)benzoic acid

Base Information

• Chemical Name: (S)-4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)benzoic acid
• CAS No.: 123993-33-9
• Molecular Formula: C₁₆H₂₁NO₆
• Molecular Weight: 323.346
• Mol file: 123993-33-9.mol

Synonyms:(S)-4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)benzoic acid

Chemical Property of (S)-4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)benzoic acid

There total 8 articles about (S)-4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

carbon monoxide (201230-82-2) + methyl N-(tert-butoxycarbonyl)-O-[(trifluoromethyl)sulfonyl]-L-tyrosinate (112766-18-4) → (S)-4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)benzoic acid (123993-33-9)

Guidance literature:

carbon monoxide; methyl N-(tert-butoxycarbonyl)-O-[(trifluoromethyl)sulfonyl]-L-tyrosinate; With 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In water; N,N-dimethyl-formamide; at 70 ℃; for 0.166667h;

With N,N-diisopropyl-1,2-ethanediamine; at 70 ℃; for 3h;

DOI:10.1002/anie.201201475

Reference yield: 73.0%

(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(2-propenyl)benzenepropanoic acid methylester (123993-26-0) → (S)-4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)benzoic acid (123993-33-9) + (S)-4-(carboxymethyl)-α-<<(1,1-dimethylethoxy)carbonyl>amino>benzenepropanoic acid methylester (123993-28-2)

Guidance literature:

With sodium periodate; sodium chlorite in NaH₂PO₄-buffer; ruthenium trichloride; Multistep reaction; 1) CCl₄, CH₃CN, water, RT, 1h, 2) tert-butylalcohol, 2-methyl-2-butene, water, 2 h;

DOI:10.1021/jo00290a021

Reference yield:

methyl 2-(S)-((tert-butoxycarbonyl)amino)-3-(4'-formyl-phenyl)propanoate (216774-45-7) → (S)-4-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)benzoic acid (123993-33-9)

Guidance literature:

With potassium permanganate; In water; acetone; at 20 ℃;

upstream raw materials:

(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-(2-propenyl)benzenepropanoic acid methylester

carbon monoxide

methyl N-(tert-butoxycarbonyl)-O-[(trifluoromethyl)sulfonyl]-L-tyrosinate

(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester