7-carbomethoxy-3-<<6-(methoxyphenyl)-5(E)-hexenyl>oxy>-9-oxo-9H-xanthene-4-propanoic acid ethyl ester

Base Information

• Chemical Name: 7-carbomethoxy-3-<<6-(methoxyphenyl)-5(E)-hexenyl>oxy>-9-oxo-9H-xanthene-4-propanoic acid ethyl ester
• CAS No.: 148291-64-9
• Molecular Formula: C₃₃H₃₄O₈
• Molecular Weight: 558.628
• Mol file: 148291-64-9.mol

Synonyms:7-carbomethoxy-3-<<6-(methoxyphenyl)-5(E)-hexenyl>oxy>-9-oxo-9H-xanthene-4-propanoic acid ethyl ester

Chemical Property of 7-carbomethoxy-3-<<6-(methoxyphenyl)-5(E)-hexenyl>oxy>-9-oxo-9H-xanthene-4-propanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-carbomethoxy-3-<<6-(methoxyphenyl)-5(E)-hexenyl>oxy>-9-oxo-9H-xanthene-4-propanoic acid ethyl ester

There total 8 articles about 7-carbomethoxy-3-<<6-(methoxyphenyl)-5(E)-hexenyl>oxy>-9-oxo-9H-xanthene-4-propanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(E)-6-(4-methoxyphenyl)-5-hexenyl methanesulfonate (134578-03-3) + 7-carbomethoxy-3-hydroxy-9-oxo-9H-xanthene-4-propanoic acid ethyl ester (135199-66-5) → 7-carbomethoxy-3-<<6-(methoxyphenyl)-5(E)-hexenyl>oxy>-9-oxo-9H-xanthene-4-propanoic acid ethyl ester (148291-64-9)

Guidance literature:

With potassium carbonate; In butanone; for 18h; Ambient temperature;

DOI:10.1021/jm00064a006

Reference yield:

O-methylresorcine (150-19-6) → 7-carbomethoxy-3-<<6-(methoxyphenyl)-5(E)-hexenyl>oxy>-9-oxo-9H-xanthene-4-propanoic acid ethyl ester (148291-64-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 32 percent / copper bronze, K₂CO₃ / pyridine / 24 h / Heating

2: 1.) 5 N aq. NaOH, 2.) P₂O₅, methane sulfonic acid / 1.) methanol, THF, RT, 24 h, 2.) methanol, THF, RT, 24 h

3: 1.) pyridine hydrochloride, 2.) water / 1.) 180-185 deg C, 3 h, 2.) RT, 18 h

4: conc. HCl / 48 h / Heating

5: 94 percent / pivalic acid / toluene / 48 h / Heating

6: 95 percent / 1 N aq. HCl / ethyl acetate / 0.5 h / Ambient temperature

7: 62 percent / K₂CO₃ / butan-2-one / 18 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; methanesulfonic acid; water; pyridine hydrochloride; phosphorus pentoxide; copper; potassium carbonate; Trimethylacetic acid; In pyridine; ethyl acetate; toluene; butanone;

DOI:10.1021/jm00064a006

Reference yield:

6-methoxy-9-oxo-9H-xanthene-2-carboxylic acid (33458-88-7) → 7-carbomethoxy-3-<<6-(methoxyphenyl)-5(E)-hexenyl>oxy>-9-oxo-9H-xanthene-4-propanoic acid ethyl ester (148291-64-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) pyridine hydrochloride, 2.) water / 1.) 180-185 deg C, 3 h, 2.) RT, 18 h

2: conc. HCl / 48 h / Heating

3: 94 percent / pivalic acid / toluene / 48 h / Heating

4: 95 percent / 1 N aq. HCl / ethyl acetate / 0.5 h / Ambient temperature

5: 62 percent / K₂CO₃ / butan-2-one / 18 h / Ambient temperature

With hydrogenchloride; water; pyridine hydrochloride; potassium carbonate; Trimethylacetic acid; In ethyl acetate; toluene; butanone;

DOI:10.1021/jm00064a006

upstream raw materials:

(E)-6-(4-methoxyphenyl)-5-hexenyl methanesulfonate

7-carbomethoxy-3-hydroxy-9-oxo-9H-xanthene-4-propanoic acid ethyl ester

O-methylresorcine

6-methoxy-9-oxo-9H-xanthene-2-carboxylic acid

Downstream raw materials:

LY 210073