134578-03-3

Basic information

• Product Name: (E)-6-(4-methoxyphenyl)-5-hexenyl methanesulfonate
• Synonyms: (E)-6-(4-methoxyphenyl)-5-hexenyl methanesulfonate
• CAS NO: 134578-03-3
• Molecular Weight: 284.376
• Mol File: 134578-03-3.mol

Chemical Properties

• CAS DataBase Reference: (E)-6-(4-methoxyphenyl)-5-hexenyl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-6-(4-methoxyphenyl)-5-hexenyl methanesulfonate(134578-03-3)
• EPA Substance Registry System: (E)-6-(4-methoxyphenyl)-5-hexenyl methanesulfonate(134578-03-3)

Safety Data

• Hazardous Substances Data: 134578-03-3(Hazardous Substances Data)

Upstream product

• 2067-33-6 5-bromopentanoic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 149109-18-2 6-acetoxy-1-(4-methoxyphenyl)hexan-1-one 
• 149109-19-3 1-(4-methoxyphenyl)hexane-1,6-diol 
• 805240-60-2 6-hydroxy-1-(4-methoxyphenyl)hexan-1-one 
• 5739-22-0 6-Acetyloxyhexanoic acid chloride 
• 81077-29-4 (E)-6-(4-methoxyphenyl)pent-5-enoic acid 
• 129887-46-3 ethyl (E)-6-(p-methoxyphenyl)-5-hexenoate 
• 17814-85-6 (4-carboxybutyl)triphenylphosphonium bromide 
• 502-44-3 hexahydro-2H-oxepin-2-one 
• 128577-60-6 (5E)-6-(4-Methoxyphenyl)-5-hexen-1-ol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 117423-74-2 LY223982 
• 197707-86-1 ethyl-4-{3-[2-(tert-butoxycarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminosulfonyl}butanoate 
• 197707-80-5 methyl 4-{3-[2-(dimethylaminocarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminocarbonyl}butanoate 
• 197707-87-2 4-{3-[2-(tert-butoxycarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminosulfonyl}butanoic acid 
• 134577-74-5 t-Butyl 3-[1-[6-(4-methoxyphenyl)hex-5E-enyl]oxy-4-(5-hydroxypentanamido)benzen-2-yl]propionate 
• 134577-72-3 4-{3-(2-tert-Butoxycarbonyl-ethyl)-4-[(E)-6-(4-methoxy-phenyl)-hex-5-enyloxy]-phenylcarbamoyl}-butyric acid 
• 197707-85-0 tert-butyl-3-{2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]-5-(4-methylphenyl)sulfonylaminophenyl}propanoate 
• 197708-46-6 tert-butyl-3-{5-(4-hydroxybutanoylamino)-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoate 
• 197707-96-3 ethyl-5-{3-[2-(ethoxycarbonyl)ethyl]-5-hydroxy-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}pentanoate 
• 134577-87-0 t-Butyl 3-[1-[6-(4-methoxyphenyl)hex-5E-enyl]oxy-4-phthalimidobenzen-2-yl]propionate 
• 197708-44-4 N-{3-(2-tert-Butoxycarbonyl-ethyl)-4-[(E)-6-(4-methoxy-phenyl)-hex-5-enyloxy]-phenyl}-succinamic acid 

Relevant articles and documents

Convenient approach for the synthesis of ONO-LB-457, a potent leukotriene B4 receptor antagonist

This study reports a new approach for the synthesis of 5-[2-(2-carboxyethyl)-3-[6-(4-methoxyphenyl)-(5E)-hexen-1-yloxy]phenoxy]pentanoic acid V (ONO-LB-457), previously described by Konno and col. and which is considered a highly potent and orally active

Trisubstituted benzene leukotriene B4 receptor antagonists: Synthesis and structure-activity relationships

A series of trisubstituted benzenes which demonstrate leukotriene B4 (LTB4, 1) receptor affinity was prepared. Previous trisubstituted benzenes from our laboratory showed high affinity to the LTB4 receptor but demonstrated

Benzophenone Dicarboxylic Acid Antagonists of Leukotriene B4. 2. Structure-Activity Relationships of the Lipophilic Side Chain

A series of lipophilic benzophenone dicarboxylic acid derivatives were found to inhibit the binding of the potent chemotoxin leukotriene B4 (LTB4) to its receptor on intact human neutrophils.Activity at the LTB4 receptor was determined by using a 3H>LTB4-binding assay.The structure-activity relationship for the lipophilic side chain was systematically investigated.Compounds with n-alkyl side chains of varying lengths were prepared and tested.Best inhibition of 3H>LTB4 binding was observed with the n-decyl derivative.Analogues with alkyl chains terminated with an aromatic ring showed improved activity.The 6-phenylhexyl side chain was optimal.Substitution on the terminal aromatic ring was also evaluated.Methoxyl, methylsulfinyl, and methyl substituents greatly enhanced the activity of the compound.For a given substituent, the para isomer had the best activity.Thus the nature of the lipophilic side chain can greatly influence the ability of the compounds to inhibit the binding of LTB4 to its receptor on intact human neutrophils.The most active compound from this series, 84 (LY223982), bound to the LTB4 receptor with the affinity approaching that of the agonist.