(2-iodophenyl)(5-methoxy-2,3-dimethyl-1H-indol-1-yl)methanone

Base Information

• Chemical Name: (2-iodophenyl)(5-methoxy-2,3-dimethyl-1H-indol-1-yl)methanone
• CAS No.: 1370410-16-4
• Molecular Formula: C₁₈H₁₆INO₂
• Molecular Weight: 405.235
• Mol file: 1370410-16-4.mol

Synonyms:(2-iodophenyl)(5-methoxy-2,3-dimethyl-1H-indol-1-yl)methanone

Chemical Property of (2-iodophenyl)(5-methoxy-2,3-dimethyl-1H-indol-1-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-iodophenyl)(5-methoxy-2,3-dimethyl-1H-indol-1-yl)methanone

There total 3 articles about (2-iodophenyl)(5-methoxy-2,3-dimethyl-1H-indol-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dimethyl-5-methoxyindole (828-94-4) + 2-Iodobenzoyl chloride (609-67-6) → (2-iodophenyl)(5-methoxy-2,3-dimethyl-1H-indol-1-yl)methanone (1370410-16-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 - 70 ℃;

DOI:10.1021/ol300584m

Reference yield:

4-methoxyphenylhydrazine hydrochloride (19501-58-7) → (2-iodophenyl)(5-methoxy-2,3-dimethyl-1H-indol-1-yl)methanone (1370410-16-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 100 °C

2: sodium hydride / N,N-dimethyl-formamide / 20 - 70 °C

With sodium hydride; acetic acid; In N,N-dimethyl-formamide; 1: Fischer reaction;

DOI:10.1021/ol300584m

Reference yield:

2-Iodobenzoic acid (88-67-5) → (2-iodophenyl)(5-methoxy-2,3-dimethyl-1H-indol-1-yl)methanone (1370410-16-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / dichloromethane / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 18 h / 70 °C / Inert atmosphere

With thionyl chloride; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.joc.0c00475

upstream raw materials:

2,3-dimethyl-5-methoxyindole

2-Iodobenzoyl chloride

4-methoxyphenylhydrazine hydrochloride

2-Iodobenzoic acid