(1R,2R)-2-[(dichloroacetyl)amino]-3-hydroxy-1-(4-nitrophenyl)propyl hexadecanoate

Base Information

• Chemical Name: (1R,2R)-2-[(dichloroacetyl)amino]-3-hydroxy-1-(4-nitrophenyl)propyl hexadecanoate
• CAS No.: 93464-25-6
• Molecular Formula: C₂₇H₄₂Cl₂N₂O₆
• Molecular Weight: 561.546
• Mol file: 93464-25-6.mol

Synonyms:(1R,2R)-2-[(dichloroacetyl)amino]-3-hydroxy-1-(4-nitrophenyl)propyl hexadecanoate

Chemical Property of (1R,2R)-2-[(dichloroacetyl)amino]-3-hydroxy-1-(4-nitrophenyl)propyl hexadecanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-2-[(dichloroacetyl)amino]-3-hydroxy-1-(4-nitrophenyl)propyl hexadecanoate

There total 3 articles about (1R,2R)-2-[(dichloroacetyl)amino]-3-hydroxy-1-(4-nitrophenyl)propyl hexadecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

vinyl palmitate (693-38-9) + chloramphenicol (56-75-7,85666-84-8) → (1R,2R)-2-[(dichloroacetyl)amino]-1-(4-nitrophenyl)-3-(palmitoyloxy)propyl palmitate (17709-53-4) + chloramphenicol Palmitate (530-43-8) + (1R,2R)-2-[(dichloroacetyl)amino]-3-hydroxy-1-(4-nitrophenyl)propyl hexadecanoate (93464-25-6)

Guidance literature:

With palmitic acid imprinted Thermomyces lanuginosus Lypozyme TL 100L lipase nanogel; In acetone; at 30 ℃; for 48h; Solvent; Green chemistry; Enzymatic reaction;

DOI:10.1039/c3gc40465j

Reference yield:

dichloroacethyl chloride (79-36-7) + (2R,3R)-2-amino-3-(4-nitro-phenyl)-3-palmitoyloxy-propan-1-ol; hydrochloride → (1R,2R)-2-[(dichloroacetyl)amino]-3-hydroxy-1-(4-nitrophenyl)propyl hexadecanoate (93464-25-6)

Guidance literature:

With N,N-dimethyl-formamide; anschliessend mit Na₂CO₃ in Aether;

DOI:10.1021/ja01606a007

Reference yield:

(2RS,3RS)-2-amino-3-(4-nitro-phenyl)-3-palmitoyloxy-propan-1-ol; hydrochloride + dichloroacetic anhydride (4124-30-5) → (2RS,3RS)-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-3-palmitoyloxy-propan-1-ol (93464-25-6,106322-61-6,125520-90-3)

Guidance literature:

With benzene;

DOI:10.1021/ja01606a007

upstream raw materials:

dichloroacethyl chloride

vinyl palmitate

chloramphenicol

dichloroacetic anhydride