[(2S,3R)-2-[(2,2-Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] hexadecanoate

Base Information

Chemical Name:[(2S,3R)-2-[(2,2-Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] hexadecanoate
CAS No.:530-43-8
Molecular Formula:C27H42Cl2N2O6
Molecular Weight:561.546
Hs Code.:29414000
NSC Number:756675
Mol file:530-43-8.mol

Synonyms:[(2S,3R)-2-[(2,2-Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] hexadecanoate;HMS2091C04;Pharmakon1600-01500172;NSC756675;CCG-212520;SBI-0206681.P002;AB01562927_01;SR-05000001583;SR-05000001583-1;BRD-K96424892-001-01-1

Suppliers and Price of [(2S,3R)-2-[(2,2-Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] hexadecanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Chloramphenicol palmitate
25g
$ 150.00

Sigma-Aldrich
Chloramphenicol palmitate United States Pharmacopeia (USP) Reference Standard
200mg
$ 366.00

Sigma-Aldrich
Chloramphenicol palmitate VETRANAL?, analytical standard
100 mg
$ 19.50

Sigma-Aldrich
Chloramphenicol palmitate nonpolymorph A United States Pharmacopeia (USP) Reference Standard
200mg
$ 1120.00

Sigma-Aldrich
Chloramphenicol palmitate polymorph A United States Pharmacopeia (USP) Reference Standard
100mg
$ 1120.00

Medical Isotopes, Inc.
Chloramphenicol palmitate
250 mg
$ 675.00

Medical Isotopes, Inc.
Chloramphenicol palmitate
100 mg
$ 610.00

Chem-Impex
Chloramphenicol palmitate 98 - 102% (Assay by titration, on dry basis)
100G
$ 45.00

Chem-Impex
Chloramphenicol palmitate 98 - 102% (Assay by titration, on dry basis)
250G
$ 90.00

Chem-Impex
Chloramphenicol palmitate 98 - 102% (Assay by titration, on dry basis)
25G
$ 20.00

Total 87 raw suppliers

Chemical Property of [(2S,3R)-2-[(2,2-Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] hexadecanoate

Chemical Property:

Appearance/Colour:white or slightly yellow crystalline powder
Vapor Pressure:4.43E-20mmHg at 25°C
Melting Point:90 °C
Refractive Index:1.525
Boiling Point:691.6 °C at 760 mmHg
PKA:10.69±0.46(Predicted)
Flash Point:372.1 °C
PSA：121.45000
Density:1.172 g/cm³
LogP:7.85530
Storage Temp.:Store at RT.
Solubility.:DMSO (Slightly), Ethanol (Sparingly), Ethyl Acetate (Slightly)
Water Solubility.:8.423ug/L(25 oC)
XLogP3:9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:21
Exact Mass:560.2419925
Heavy Atom Count:37
Complexity:639

Purity/Quality:

99%, ^*data from raw suppliers

Chloramphenicol palmitate ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 40-36/37/38-20/21/22
Safety Statements: 36/37-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCCCCCCCCCCCCCCC(=O)OCC(C(C1=CC=C(C=C1)[N+](=O)[O-])O)NC(=O)C(Cl)Cl
Isomeric SMILES:CCCCCCCCCCCCCCCC(=O)OC[C@@H]([C@@H](C1=CC=C(C=C1)[N+](=O)[O-])O)NC(=O)C(Cl)Cl
Description Chloramphenicol palmitate is an orally bioavailable ester prodrug form of the antibiotic chloramphenicol. It is hydrolyzed in the small intestine to release chloramphenicol. Formulations containing chloramphenicol palmitate were previously used in the treatment of severe bacterial infections.
Uses Chloramphenicol Palmitate is a Chloramphenicol (C325030) derivative, a broad spectrum antibiotic obtained from cultures of the soil bacterium Streptomyces venezuelae. It has a broad spectrum of activity against Gram-positive and gram-negative bacteria. Antibacterial; antirickettsial. antibacterial, antirickettsial Chloramphenicol palmitate is prepared by acylation of chloramphenicol with palmitic acid. Although chloramphenicol palmitate is a more hydrophobic drug which should enhance bioavailability, the primary advantage of the ester is to mask the taste of chloramphenicol in oral formulations. Chloramphenicol palmitate is significantly less active than chloramphenicol but acts as a prodrug, being readily hydrolysed by acid and esterase in the gut to release chloramphenicol.
Therapeutic Function Antibacterial; Antirickettsial

Technology Process of [(2S,3R)-2-[(2,2-Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] hexadecanoate

There total 17 articles about [(2S,3R)-2-[(2,2-Dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] hexadecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1104640-94-9
3-nitro-1-palmitoyl-1H-1,2,4-triazole

: 56-75-7,85666-84-8
chloramphenicol

: 530-43-8
chloramphenicol Palmitate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 1h; regioselective reaction;
DOI:10.3987/COM-08-S(N)95

Reference yield: 99.0%

: 693-38-9
vinyl palmitate

: 56-75-7,85666-84-8
chloramphenicol

: 530-43-8
chloramphenicol Palmitate

Guidance literature:: With palmitic acid imprinted Thermomyces lanuginosus Lypozyme TL 100L lipase nanogel; In acetonitrile; at 20 ℃; for 48h; Temperature; Concentration; Reagent/catalyst; regioselective reaction; Green chemistry; Enzymatic reaction;
DOI:10.1039/c3gc40465j