1-(3-chloro-4-fluoro-benzylamino)-1H-pyrrole-2-carboxylic acid allyl ester

Base Information

Chemical Name:1-(3-chloro-4-fluoro-benzylamino)-1H-pyrrole-2-carboxylic acid allyl ester
CAS No.:1000313-21-2
Molecular Formula:C₁₅H₁₄ClFN₂O₂
Molecular Weight:308.74
Hs Code.:

Synonyms:1-(3-chloro-4-fluoro-benzylamino)-1H-pyrrole-2-carboxylic acid allyl ester

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Chemical Property of 1-(3-chloro-4-fluoro-benzylamino)-1H-pyrrole-2-carboxylic acid allyl ester

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Technology Process of 1-(3-chloro-4-fluoro-benzylamino)-1H-pyrrole-2-carboxylic acid allyl ester

There total 2 articles about 1-(3-chloro-4-fluoro-benzylamino)-1H-pyrrole-2-carboxylic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 34328-61-5
3-Chloro-4-fluorobenzaldehyde

: 35889-85-1
prop-2-enyl 1H-pyrrole-2-carboxylate

: 1000313-21-2
1-(3-chloro-4-fluoro-benzylamino)-1H-pyrrole-2-carboxylic acid allyl ester

Guidance literature:: With sodium cyanoborohydride; In methanol; acetic acid; at 25 ℃; for 18h;

Reference yield:

: 634-97-9
pyrrole-2-carboxyl acid

: 1000313-21-2
1-(3-chloro-4-fluoro-benzylamino)-1H-pyrrole-2-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 25 °C

2: sodium cyanoborohydride / methanol; acetic acid / 18 h / 25 °C

With sodium cyanoborohydride; caesium carbonate; In methanol; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1000313-21-2
1-(3-chloro-4-fluoro-benzylamino)-1H-pyrrole-2-carboxylic acid allyl ester

: 1000313-20-1
(7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ6-benzo[e][1,2,4]thiadiazin-3-yl)-acetic acid

: 1000313-22-3
1-{(3-chloro-4-fluoro-benzyl)-[2-(7-methanesulfonylmethyl-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-acetyl]-amino}-1H-pyrrole-2-carboxylic acid allyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/j.bmcl.2008.04.066