1000313-22-3Relevant academic research and scientific papers
Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase
Ruebsam, Frank,Webber, Stephen E.,Tran, Martin T.,Tran, Chinh V.,Murphy, Douglas E.,Zhao, Jingjing,Dragovich, Peter S.,Kim, Sun Hee,Li, Lian-Sheng,Zhou, Yuefen,Han, Qing,Kissinger, Charles R.,Showalter, Richard E.,Lardy, Matthew,Shah, Amit M.,Tsan, Mei,Patel, Rupal,LeBrun, Laurie A.,Kamran, Ruhi,Sergeeva, Maria V.,Bartkowski, Darian M.,Nolan, Thomas G.,Norris, Daniel A.,Kirkovsky, Leo
scheme or table, p. 3616 - 3621 (2009/04/06)
Pyrrolo[1,2-b]pyridazin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Structure-based design led to the discovery of compound 3k, which displayed potent inhibitory activities in biochemical and replicon as
PYRRO[1,2-B]PYRIDAZINONE COMPOUNDS
-
, (2008/06/13)
The invention is directed to pyrro[l,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
