(R)-N-(3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-yl)-2-fluoro-5-(trifluoromethyl)benzamide

Base Information

• Chemical Name: (R)-N-(3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-yl)-2-fluoro-5-(trifluoromethyl)benzamide
• CAS No.: 1140917-50-5
• Molecular Formula: C₂₀H₂₃F₄N₃O₂
• Molecular Weight: 413.415
• Mol file: 1140917-50-5.mol

Synonyms:(R)-N-(3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-yl)-2-fluoro-5-(trifluoromethyl)benzamide

Chemical Property of (R)-N-(3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-yl)-2-fluoro-5-(trifluoromethyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-(3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-yl)-2-fluoro-5-(trifluoromethyl)benzamide

There total 7 articles about (R)-N-(3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-yl)-2-fluoro-5-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-fluoro-5-(trifluoromethyl)benzoyl chloride (207981-46-2) + (R)-3-tert-butyl-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-amine hydrochloride (1140917-98-1) → (R)-N-(3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-yl)-2-fluoro-5-(trifluoromethyl)benzamide (1140917-50-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 3.16667h;

Reference yield: 67.0%

(R)-3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-amine (1141016-83-2) + 2-fluoro-5-(trifluoromethyl)benzoic acid (115029-23-7) → (R)-N-(3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-yl)-2-fluoro-5-(trifluoromethyl)benzamide (1140917-50-5)

Guidance literature:

2-fluoro-5-(trifluoromethyl)benzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

(R)-3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-amine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.ejmech.2020.113087

Reference yield:

2-fluoro-5-(trifluoromethyl)benzoyl chloride (207981-46-2) + (R)-3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-amine (1141016-83-2) → (R)-N-(3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-yl)-2-fluoro-5-(trifluoromethyl)benzamide (1140917-50-5)

Guidance literature:

2-fluoro-5-(trifluoromethyl)benzoyl chloride; (R)-3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-amine; With triethylamine; In tetrahydrofuran; at 20 ℃; for 3.16h;

With sodium hydrogencarbonate; In tetrahydrofuran; water;

upstream raw materials:

2-fluoro-5-(trifluoromethyl)benzoyl chloride

(R)-3-(tert-butyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-amine

(R)-3-tert-butyl-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-amine

(R)-3-tert-butyl-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-5-amine hydrochloride

Downstream raw materials:

N-{(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}-2-fluoro-5-(trifluoromethyl)benzamide

methyl 3-[2-[({(3E)-5-tert-butyl-1-methyl-2-[(2R)-tetrahydrofuran-2-ylmethyl]-1,2-dihydro-3H-pyrazol-3-ylidene}amino)carbonyl]-4-(trifluoromethyl)phenoxy]-2,2-dimethylpropanoate