4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl methanesulfonate

Base Information

Chemical Name:4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl methanesulfonate
CAS No.:955360-05-1
Molecular Formula:C₂₀H₃₃NO₄S
Molecular Weight:383.552
Hs Code.:

Synonyms:4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl methanesulfonate

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Chemical Property of 4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl methanesulfonate

Chemical Property:

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Technology Process of 4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl methanesulfonate

There total 8 articles about 4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 955360-04-0
4-(4-[3-(hexahydro-1H-azepin-1-yl)propoxy]phenyl)-1-butanol

: 124-63-0
methanesulfonyl chloride

: 955360-05-1
4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl methanesulfonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm1013874

Reference yield:

: 273217-89-3
1-(3-chloropropoxy)-4-iodobenzene

: 955360-05-1
4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium iodide / butanone / 22 h / 80 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

3: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; ethanol / 4 h

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; butanone; 2: Sonogashira coupling;
DOI:10.1021/jm1013874

Reference yield:

: 955360-02-8
1-[3-(4-iodophenoxy)propyl]-hexahydro-1H-azepine

: 955360-05-1
4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

2: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; ethanol / 4 h

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1: Sonogashira coupling;
DOI:10.1021/jm1013874