1-N-[2-(3,4-dimethoxy-2-trifluoromethylphenyl)-2-hydroxyethyl]formamide

Base Information

Chemical Name:1-N-[2-(3,4-dimethoxy-2-trifluoromethylphenyl)-2-hydroxyethyl]formamide
CAS No.:634924-76-8
Molecular Formula:C₁₂H₁₄F₃NO₄
Molecular Weight:293.243
Hs Code.:

Synonyms:1-N-[2-(3,4-dimethoxy-2-trifluoromethylphenyl)-2-hydroxyethyl]formamide

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Chemical Property of 1-N-[2-(3,4-dimethoxy-2-trifluoromethylphenyl)-2-hydroxyethyl]formamide

Chemical Property:

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Technology Process of 1-N-[2-(3,4-dimethoxy-2-trifluoromethylphenyl)-2-hydroxyethyl]formamide

There total 6 articles about 1-N-[2-(3,4-dimethoxy-2-trifluoromethylphenyl)-2-hydroxyethyl]formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-94-4
formic acid ethyl ester

: 634924-71-3
(1S)-2-amino-1-(3,4-dimethoxy-2-trifluoromethylphenyl)ethanol

: 634924-76-8
1-N-[2-(3,4-dimethoxy-2-trifluoromethylphenyl)-2-hydroxyethyl]formamide

Guidance literature:: for 3h; Heating;
DOI:10.1016/j.tetlet.2004.02.040

Reference yield:

: 621-59-0
isovanillin

: 634924-76-8
1-N-[2-(3,4-dimethoxy-2-trifluoromethylphenyl)-2-hydroxyethyl]formamide

Guidance literature:: Multi-step reaction with 6 steps

1: 69.3 percent / iodine monochloride; pyridine / dioxane / 0 - 20 °C

2: 72.2 percent / K₂CO₃ / acetone / 6 h / Heating

3: 25.1 percent / N-methyl-2-pyrrolidinone; CuI / 4 h / 175 °C

4: 75.1 percent / (R,R)-salen; titanium tetraisopropoxide / CH₂Cl₂ / 120 h / -50 °C

5: 53.2 percent / LiAlH₄ / diethyl ether / 0 - 20 °C

6: 3 h / Heating

With pyridine; 1-methyl-pyrrolidin-2-one; titanium(IV) isopropylate; copper(l) iodide; lithium aluminium tetrahydride; (R,R)-N,N'-bis(salicylidene)-1,2-cyclohexanediamine; Iodine monochloride; potassium carbonate; In 1,4-dioxane; diethyl ether; dichloromethane; acetone;
DOI:10.1016/j.tetlet.2004.02.040

Reference yield:

: 138490-95-6
2-iodo-3,4-dimethoxybenzaldehyde

: 634924-76-8
1-N-[2-(3,4-dimethoxy-2-trifluoromethylphenyl)-2-hydroxyethyl]formamide

Guidance literature:: Multi-step reaction with 4 steps

1: 25.1 percent / N-methyl-2-pyrrolidinone; CuI / 4 h / 175 °C

2: 75.1 percent / (R,R)-salen; titanium tetraisopropoxide / CH₂Cl₂ / 120 h / -50 °C

3: 53.2 percent / LiAlH₄ / diethyl ether / 0 - 20 °C

4: 3 h / Heating

With 1-methyl-pyrrolidin-2-one; titanium(IV) isopropylate; copper(l) iodide; lithium aluminium tetrahydride; (R,R)-N,N'-bis(salicylidene)-1,2-cyclohexanediamine; In diethyl ether; dichloromethane;
DOI:10.1016/j.tetlet.2004.02.040