7-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-(toluene-4-sulfonyl)-2,3,5,9-tetrahydro-1,5,8,9-tetraaza-cyclopenta[e]acenaphthylen-6-one

Base Information

Chemical Name:7-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-(toluene-4-sulfonyl)-2,3,5,9-tetrahydro-1,5,8,9-tetraaza-cyclopenta[e]acenaphthylen-6-one
CAS No.:892113-84-7
Molecular Formula:C₂₇H₂₁N₅O₅S
Molecular Weight:527.56
Hs Code.:

7-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1<i>H</i>-indol-3-yl)-5-(toluene-4-sulfonyl)-2,3,5,9-tetrahydro-1,5,8,9-tetraaza-cyclopenta[<i>e</i>]acenaphthylen-6-one

Synonyms:7-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-(toluene-4-sulfonyl)-2,3,5,9-tetrahydro-1,5,8,9-tetraaza-cyclopenta[e]acenaphthylen-6-one

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Chemical Property of 7-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-(toluene-4-sulfonyl)-2,3,5,9-tetrahydro-1,5,8,9-tetraaza-cyclopenta[e]acenaphthylen-6-one

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Technology Process of 7-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-(toluene-4-sulfonyl)-2,3,5,9-tetrahydro-1,5,8,9-tetraaza-cyclopenta[e]acenaphthylen-6-one

There total 15 articles about 7-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-(toluene-4-sulfonyl)-2,3,5,9-tetrahydro-1,5,8,9-tetraaza-cyclopenta[e]acenaphthylen-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 892113-17-6
tert-butyl (2-{1-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-[(4-methylphenyl)sulfonyl]-4,8-dioxo-1,4,5,8-tetrahydro-pyrrolo[2,3-f]indazol-7-yl}ethyl)carbamate

: 892113-84-7
7-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-(toluene-4-sulfonyl)-2,3,5,9-tetrahydro-1,5,8,9-tetraaza-cyclopenta[e]acenaphthylen-6-one

Guidance literature:: tert-butyl (2-{1-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-[(4-methylphenyl)sulfonyl]-4,8-dioxo-1,4,5,8-tetrahydro-pyrrolo[2,3-f]indazol-7-yl}ethyl)carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With 4 A molecular sieve; sodium hydrogencarbonate; In ethanol; for 1.5h; Heating;
DOI:10.1021/jm051247f

Reference yield:

: 23876-39-3
4,7-dimethoxylindole

: 892113-84-7
7-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-(toluene-4-sulfonyl)-2,3,5,9-tetrahydro-1,5,8,9-tetraaza-cyclopenta[e]acenaphthylen-6-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: POCl₃ / 1.5 h / 0 °C

2.1: ammonium acetate; acetic acid / 3 h / Heating

3.1: KOH / tetrahydrofuran / 0.08 h / 0 °C

3.2: 54 percent / tetrahydrofuran / 1 h / 20 °C

4.1: LiAlH₄ / diethyl ether; CH₂Cl₂ / 0.25 h / 0 °C

5.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C

5.2: 200 mg / tetrahydrofuran / 1 h / 20 °C

6.1: CAN / acetonitrile; H₂O / 0.25 h / 20 °C

7.1: 360 mg / tetrahydrofuran; diethyl ether / 1 h

8.1: TFA / CH₂Cl₂ / 0.5 h / 20 °C

8.2: 4 Angstroem molecular sieve; NaHCO₃ / ethanol / 1.5 h / Heating

With ammonium acetate; potassium hydroxide; lithium aluminium tetrahydride; ammonium cerium(IV) nitrate; sodium hydride; acetic acid; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1021/jm051247f

Reference yield:

: 409095-61-0
3-diazomethyl-3-hydroxy-1-methyl-1,3-dihydro-indol-2-one

: 892113-84-7
7-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-(toluene-4-sulfonyl)-2,3,5,9-tetrahydro-1,5,8,9-tetraaza-cyclopenta[e]acenaphthylen-6-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 360 mg / tetrahydrofuran; diethyl ether / 1 h

2.1: TFA / CH₂Cl₂ / 0.5 h / 20 °C

2.2: 4 Angstroem molecular sieve; NaHCO₃ / ethanol / 1.5 h / Heating

With trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jm051247f