23876-39-3

Basic information

• Product Name: 4,7-DIMETHOXY-1H-INDOLE
• Synonyms: 4,7-DIMETHOXYINDOLE;1H-Indole, 4,7-diMethoxy-
• CAS NO: 23876-39-3
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.2047
• Mol File: 23876-39-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 204-205 °C
• Boiling Point: 346.0±22.0 °C(Predicted)
• Appearance: /
• Density: 1.182±0.06 g/cm3(Predicted)
• PKA: 16.71±0.30(Predicted)
• CAS DataBase Reference: 4,7-DIMETHOXY-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,7-DIMETHOXY-1H-INDOLE(23876-39-3)
• EPA Substance Registry System: 4,7-DIMETHOXY-1H-INDOLE(23876-39-3)

Safety Data

• Hazardous Substances Data: 23876-39-3(Hazardous Substances Data)

Usage

General Description

4,7-DIMETHOXY-1H-INDOLE is a chemical compound with the molecular formula C10H11NO2. It belongs to the class of indole derivatives and is characterized by the presence of two methoxy (CH3O) groups at the 4 and 7 positions of the indole ring. 4,7-DIMETHOXY-1H-INDOLE has been studied for its potential pharmacological properties, including its use in the development of new drugs for various medical conditions. 4,7-DIMETHOXY-1H-INDOLE has shown potential in research related to its anti-inflammatory, antioxidant, and neuroprotective activities, with potential implications for the treatment of neurological disorders and other diseases. Further research into the properties and potential applications of 4,7-DIMETHOXY-1H-INDOLE is ongoing.

Upstream product

• 637-39-8 triethanolamine hydrochloride 
• 102-56-7 2,5-dimethoxyaniline 
• 146432-92-0 ethyl 4,7-dimethoxy-1H-indole-2-carboxylate 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 1206-55-9 3,6-dimethoxy-2-nitrobenzaldehyde 
• 31271-83-7 4,7-dimethoxy-1H-indole-2-carboxylic acid 
• 143814-63-5 (E)-1,4-Dimethoxy-2-nitro-3-(2-nitroethenyl)benzene 
• 102-71-6 triethanolamine 
• 144900-08-3 N-(trifluoroacetyl)-2-(2,5-dimethoxyanilino)acetaldehyde diethyl acetal 

Downstream Products

• 170489-17-5 4,7-dimethoxy-1H-indole-3-carboxaldehyde 
• 1421942-25-7 3-acetyl-4,7-dimethoxy-1-(2,4-dichlorobenzyl)-1H-indole 
• 1421942-33-7 4-[1-(2,4-dichlorobenzyl)-4,7-dimethoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid 
• 1421942-29-1 ethyl 4-[1-(2,4-dichlorobenzyl)-4,7-dimethoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate 
• 55099-13-3 3-acetyl-4,7-dimethoxy-1H-indole 
• 1064710-54-8 4-[1-(4-fluorobenzyl)-4,7-dimethoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid 
• 1064710-50-4 ethyl 4-[1-(4-fluorobenzyl)-4,7-dimethoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate 
• 1036765-54-4 3-acetyl-1-(4-fluorobenzyl)-4,7-dimethoxy-1H-indole 
• 78942-65-1 3-(4,7-dihydroxy)indolyl benzyl ketone 
• 78942-72-0 4,7-dihydroxyindole-3-carbonyl chloride 
• 50469-21-1 4,7-dioxoindole-3-carboxylic acid 
• 220034-56-0 Dibenzyl-{2-[4,7-dimethoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-ethyl}-amine 
• 805953-02-0 N,N-dibenzyl-4,7-dimethoxytryptamine 
• 538368-22-8 N-{2-[4,9-dioxo-1-(toluene-4-sulfonyl)-4,9-dihydro-1H-pyrrolo[2,3-g]quinolin-8-yl]-phenyl}-2,2,2-trifluoro-acetamide 

Relevant articles and documents

Synthesis and antiprotozoal evaluation of benzothiazolopyrroloquinoxalinones, analogues of kuanoniamine A

Boc-aminoethylindoloquinone 8, a key intermediate for the building of pentacyclic quinoneimines, analogues of kuanoniamine A, was synthesized by alkylation of 4,7-dimethoxyindole 3 with 1,2-dibromoethane followed by transformation into azide, reduction of the latter with trimethylphosphine in the presence of 2-(tert-butoxycarbonyloximino)-2-phenylacetonitrile and oxydative demethylation of the Boc-amine 6 with silver(II) oxide. Quinone 8 was then treated in situ with the thiazole o-quinodimethane 10 to afford a regioisomeric mixture of the tetracyclic quinones 11. Treatment of the mixture with trifluoroacetic acid and molecular sieves 4-A provided the corresponding quinoneimines 12. Separation of the regioisomers was performed by preparative thin-layer chromatography on silica gel. The structural assignment was made by 2D 1H-13C HMBC correlations performed on the less polar regioisomer 12b. In vitro anti-leishmanial assays showed that the tested compounds possess a good potency towards two Leishmania sp. as well as against a virulent strain of Toxoplasma gondii and without any cytotoxicity against THP-1 cells.

Synthesis and cytotoxic activity of 2-acyl-1H-indole-4,7-diones on human cancer cell lines

Synthesis and cytotoxic activity of a series of 2-acyl-1H-indole-4,7-diones on human cancer cell lines are described. Due to close structural relationship to 2-acylindoles, potent inhibitors of tubulin polymerization, the mode of action of these novel com

Synthesis of novel pentacyclic pyrrolothiazolobenzoquinolinones, analogs of natural marine alkaloids

Multistep synthesis (12 steps) of new pentacyclic compounds, which are structurally very close to natural marine alkaloids, was performed via a Diels-Alder reaction between 4-methylene-5-(bromomethylene)-4,5-dihydrothiazole and a protected dioxotryptamine