5-(3-(4-fluorobenzo[d]oxazol-2-yl)-4-methoxyphenyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:5-(3-(4-fluorobenzo[d]oxazol-2-yl)-4-methoxyphenyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylsulfonamido)benzofuran-3-carboxamide
CAS No.:1333241-64-7
Molecular Formula:C₃₂H₂₅F₂N₃O₆S
Molecular Weight:617.63
Hs Code.:

Synonyms:5-(3-(4-fluorobenzo[d]oxazol-2-yl)-4-methoxyphenyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylsulfonamido)benzofuran-3-carboxamide

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Chemical Property of 5-(3-(4-fluorobenzo[d]oxazol-2-yl)-4-methoxyphenyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylsulfonamido)benzofuran-3-carboxamide

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Technology Process of 5-(3-(4-fluorobenzo[d]oxazol-2-yl)-4-methoxyphenyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylsulfonamido)benzofuran-3-carboxamide

There total 18 articles about 5-(3-(4-fluorobenzo[d]oxazol-2-yl)-4-methoxyphenyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1333244-41-9
4-fluoro-2-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzo[d]oxazole

: 1333225-20-9
5-bromo-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzo furan-3-carboxamide

: 1333241-64-7
5-(3-(4-fluorobenzo[d]oxazol-2-yl)-4-methoxyphenyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 100 ℃; for 10h; Inert atmosphere;

Reference yield:

: 19064-24-5
2,6-difluoro-1-nitrobenzene

: 1333241-64-7
5-(3-(4-fluorobenzo[d]oxazol-2-yl)-4-methoxyphenyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: methanol / 15 h / 0 - 20 °C

2: boron tribromide / dichloromethane / 15 h / -40 - 20 °C

3: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 20 °C / 760.05 Torr

4: 4 h / 140 °C

5: potassium acetate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

6: potassium phosphate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere

With potassium phosphate; hydrogen; potassium acetate; boron tribromide; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 385-01-3
2-nitro-3-fluorophenol

: 1333241-64-7
5-(3-(4-fluorobenzo[d]oxazol-2-yl)-4-methoxyphenyl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 20 °C / 760.05 Torr

2: 4 h / 140 °C

3: potassium acetate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

4: potassium phosphate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / N,N-dimethyl-formamide / 10 h / 100 °C / Inert atmosphere

With potassium phosphate; hydrogen; potassium acetate; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); palladium 10% on activated carbon; In ethanol; N,N-dimethyl-formamide;