4-(2,6-Dichloro-phenoxy)-1-{(2R,3R,4S,5S)-3-hydroxy-5-hydroxymethyl-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidin-2-one

Base Information

Chemical Name:4-(2,6-Dichloro-phenoxy)-1-{(2R,3R,4S,5S)-3-hydroxy-5-hydroxymethyl-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidin-2-one
CAS No.:174088-55-2
Molecular Formula:C₂₅H₂₆Cl₂N₂O₇
Molecular Weight:537.397
Hs Code.:

Synonyms:4-(2,6-Dichloro-phenoxy)-1-{(2R,3R,4S,5S)-3-hydroxy-5-hydroxymethyl-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidin-2-one

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Chemical Property of 4-(2,6-Dichloro-phenoxy)-1-{(2R,3R,4S,5S)-3-hydroxy-5-hydroxymethyl-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidin-2-one

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Technology Process of 4-(2,6-Dichloro-phenoxy)-1-{(2R,3R,4S,5S)-3-hydroxy-5-hydroxymethyl-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidin-2-one

There total 3 articles about 4-(2,6-Dichloro-phenoxy)-1-{(2R,3R,4S,5S)-3-hydroxy-5-hydroxymethyl-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 174088-54-1
Acetic acid (2R,3R,4R,5S)-5-acetoxymethyl-2-[4-(2,6-dichloro-phenoxy)-5-methyl-2-oxo-2H-pyrimidin-1-yl]-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-3-yl ester

: 174088-55-2
4-(2,6-Dichloro-phenoxy)-1-{(2R,3R,4S,5S)-3-hydroxy-5-hydroxymethyl-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidin-2-one

Guidance literature:: With sodium hydroxide; In methanol; at 0 ℃; for 1h;
DOI:10.1080/15257779508010717

Reference yield:

: 87-65-0
2,6-Dichlorophenol

: 174088-55-2
4-(2,6-Dichloro-phenoxy)-1-{(2R,3R,4S,5S)-3-hydroxy-5-hydroxymethyl-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NEt₃, 2-methylenesulfonyl chloride, DMF, 2.) DBU / 1.) CH₂Cl₂, 30 min, 2.) 1 h

2: 91 percent / aq. NaOH / methanol / 1 h / 0 °C

With sodium hydroxide; 2-methylenesulfonyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In methanol;
DOI:10.1080/15257779508010717

Reference yield:

: 144944-85-4
2',5'-di-O-acetyl-3'-deoxy-3'-C-(2-hydroxyethyl)-2-O-para-methoxyphenyl-(β-D-ribofuranosyl)thymine

: 174088-55-2
4-(2,6-Dichloro-phenoxy)-1-{(2R,3R,4S,5S)-3-hydroxy-5-hydroxymethyl-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NEt₃, 2-methylenesulfonyl chloride, DMF, 2.) DBU / 1.) CH₂Cl₂, 30 min, 2.) 1 h

2: 91 percent / aq. NaOH / methanol / 1 h / 0 °C

With sodium hydroxide; 2-methylenesulfonyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In methanol;
DOI:10.1080/15257779508010717