Acetic acid (2R,3R,4R,5S)-5-acetoxymethyl-2-[4-(2,6-dichloro-phenoxy)-5-methyl-2-oxo-2H-pyrimidin-1-yl]-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Acetic acid (2R,3R,4R,5S)-5-acetoxymethyl-2-[4-(2,6-dichloro-phenoxy)-5-methyl-2-oxo-2H-pyrimidin-1-yl]-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-3-yl ester
CAS No.:174088-54-1
Molecular Formula:C₂₉H₃₀Cl₂N₂O₉
Molecular Weight:621.471
Hs Code.:

Acetic acid (2R,3R,4R,5S)-5-acetoxymethyl-2-[4-(2,6-dichloro-phenoxy)-5-methyl-2-oxo-2H-pyrimidin-1-yl]-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-3-yl ester

Synonyms:Acetic acid (2R,3R,4R,5S)-5-acetoxymethyl-2-[4-(2,6-dichloro-phenoxy)-5-methyl-2-oxo-2H-pyrimidin-1-yl]-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-3-yl ester

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Chemical Property of Acetic acid (2R,3R,4R,5S)-5-acetoxymethyl-2-[4-(2,6-dichloro-phenoxy)-5-methyl-2-oxo-2H-pyrimidin-1-yl]-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-3-yl ester

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Technology Process of Acetic acid (2R,3R,4R,5S)-5-acetoxymethyl-2-[4-(2,6-dichloro-phenoxy)-5-methyl-2-oxo-2H-pyrimidin-1-yl]-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-3-yl ester

There total 1 articles about Acetic acid (2R,3R,4R,5S)-5-acetoxymethyl-2-[4-(2,6-dichloro-phenoxy)-5-methyl-2-oxo-2H-pyrimidin-1-yl]-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87-65-0
2,6-Dichlorophenol

: 144944-85-4
2',5'-di-O-acetyl-3'-deoxy-3'-C-(2-hydroxyethyl)-2-O-para-methoxyphenyl-(β-D-ribofuranosyl)thymine

: 174088-54-1
Acetic acid (2R,3R,4R,5S)-5-acetoxymethyl-2-[4-(2,6-dichloro-phenoxy)-5-methyl-2-oxo-2H-pyrimidin-1-yl]-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-3-yl ester

Guidance literature:: With 2-methylenesulfonyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; Yield given. Multistep reaction; 1.) CH₂Cl₂, 30 min, 2.) 1 h;
DOI:10.1080/15257779508010717

Reference yield: 91.0%

: 174088-54-1
Acetic acid (2R,3R,4R,5S)-5-acetoxymethyl-2-[4-(2,6-dichloro-phenoxy)-5-methyl-2-oxo-2H-pyrimidin-1-yl]-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-3-yl ester

: 174088-55-2
4-(2,6-Dichloro-phenoxy)-1-{(2R,3R,4S,5S)-3-hydroxy-5-hydroxymethyl-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-1H-pyrimidin-2-one

Guidance literature:: With sodium hydroxide; In methanol; at 0 ℃; for 1h;
DOI:10.1080/15257779508010717

Reference yield:

: 174088-54-1
Acetic acid (2R,3R,4R,5S)-5-acetoxymethyl-2-[4-(2,6-dichloro-phenoxy)-5-methyl-2-oxo-2H-pyrimidin-1-yl]-4-[2-(4-methoxy-phenoxy)-ethyl]-tetrahydro-furan-3-yl ester

: 174088-59-6
1-[(2R,3R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2-hydroxy-ethyl)-3-methoxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / aq. NaOH / methanol / 1 h / 0 °C

2: 81 percent / imidazole / dimethylformamide / 6 h / Ambient temperature

3: 98 percent / NaH / dimethylformamide / 1 h / 0 °C

4: 85 percent / 4-nitrobenzaldoxime, 1,1,3,3-tetramethylguanidine / methanol; acetonitrile / 10 h / Ambient temperature

5: 72 percent / cerium ammonium nitrate / acetonitrile; methanol / 0.5 h / 0 °C

With 1H-imidazole; sodium hydroxide; ammonium cerium(IV) nitrate; sodium hydride; N,N,N',N'-tetramethylguanidine; 4-nitrobenzaldehyde oxime; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1080/15257779508010717