(S)-2-(9-Phenyl-9H-fluoren-9-ylamino)-hexanedioic acid 1-tert-butyl ester

Base Information

Chemical Name:(S)-2-(9-Phenyl-9H-fluoren-9-ylamino)-hexanedioic acid 1-tert-butyl ester
CAS No.:215182-79-9
Molecular Formula:C₂₉H₃₁NO₄
Molecular Weight:457.569
Hs Code.:

Synonyms:(S)-2-(9-Phenyl-9H-fluoren-9-ylamino)-hexanedioic acid 1-tert-butyl ester

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Chemical Property of (S)-2-(9-Phenyl-9H-fluoren-9-ylamino)-hexanedioic acid 1-tert-butyl ester

Chemical Property:

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Technology Process of (S)-2-(9-Phenyl-9H-fluoren-9-ylamino)-hexanedioic acid 1-tert-butyl ester

There total 6 articles about (S)-2-(9-Phenyl-9H-fluoren-9-ylamino)-hexanedioic acid 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 147698-06-4
1-tert-Butyl 6-methyl (S)-2-[N-(9-phenylfluoren-9-yl)amino]hexandioate

: 215182-79-9
(S)-2-(9-Phenyl-9H-fluoren-9-ylamino)-hexanedioic acid 1-tert-butyl ester

Guidance literature:: With lithium hydroxide; In 1,4-dioxane; for 2h; Heating;
DOI:10.1021/jo9814602

Reference yield:

: 120230-41-3
N-(9-phenylfluoren-9-yl)-L-aspartic acid α-t-butyl β-methyl diester

: 215182-79-9
(S)-2-(9-Phenyl-9H-fluoren-9-ylamino)-hexanedioic acid 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / DIBAL-H / tetrahydrofuran / 0.5 h / -40 °C

2: 91 percent / DMSO, (COCl)2 / CH₂Cl₂ / 4 h / -60 °C

3: 93 percent / tetrahydrofuran / 24 h / Heating

4: 99 percent / H₂ / Pd/C / ethyl acetate / 16 h / 2090 Torr

5: 94 percent / LiOH / dioxane / 2 h / Heating

With lithium hydroxide; oxalyl dichloride; hydrogen; diisobutylaluminium hydride; dimethyl sulfoxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate;
DOI:10.1021/jo9814602

Reference yield:

: 126218-06-2
(S)-4-methoxy-4-oxo-2-((9-phenyl-9H-fluoren-9-yl)amino)butanoic acid

: 215182-79-9
(S)-2-(9-Phenyl-9H-fluoren-9-ylamino)-hexanedioic acid 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / CH₂Cl₂ / 72 h

2: 96 percent / DIBAL-H / tetrahydrofuran / 0.5 h / -40 °C

3: 91 percent / DMSO, (COCl)2 / CH₂Cl₂ / 4 h / -60 °C

4: 93 percent / tetrahydrofuran / 24 h / Heating

5: 99 percent / H₂ / Pd/C / ethyl acetate / 16 h / 2090 Torr

6: 94 percent / LiOH / dioxane / 2 h / Heating

With lithium hydroxide; oxalyl dichloride; hydrogen; diisobutylaluminium hydride; dimethyl sulfoxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate;
DOI:10.1021/jo9814602