120230-41-3Relevant articles and documents
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology
Lu, Min,Zhang, Hongjun,Li, Derun,Childers, Matthew,Pu, Qinglin,Palte, Rachel L.,Gathiaka, Symon,Lyons, Thomas W.,Palani, Anandan,Fan, Peter W.,Spacciapoli, Peter,Miller, J. Richard,Cho, Hyelim,Cheng, Mangeng,Chakravarthy, Kalyan,O'Neil, Jennifer,Eangoor, Padmanabhan,Beard, Adam,Kim, Hai-Young,Saurí, Josep,Gunaydin, Hakan,Sloman, David L.,Siliphaivanh, Phieng,Cumming, Jared,Fischer, Christian
, p. 1380 - 1388 (2021)
Recent data suggest that the inhibition of arginase (ARG) has therapeutic potential for the treatment of a number of indications ranging from pulmonary and vascular disease to cancer. Thus, high demand exists for selective small molecule ARG inhibitors wi
Native chemical ligation at valine: A contribution to peptide and glycopeptide synthesis
Chen, Jin,Wan, Qian,Yuan, Yu,Zhu, Jianglong,Danishefsky, Samuel J.
supporting information; experimental part, p. 8521 - 8524 (2009/05/07)
(Chemical Equation Presented) A Val-uable link: The title transformation is achieved by a two-step ligation, radicalbased desulfurization strategy (see scheme; NCL=native chemical ligation). After S→N acyl transfer, in which the acyl acceptor is a γ-thiol valine derivative, and site-specific dethiolation, a valine residue appears at the site of ligation. This method accomplishes ligations at Thr-Val and Pro-Val sites, and allows successful ligation of glycopeptide fragments.
An efficient and practical total synthesis of (+)-vincamine from L-aspartic acid
Gmeiner,Feldman,Chu-Moyer,Rapoport
, p. 3068 - 3074 (2007/10/02)
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