N-(tert-butoxycarbonyl)-N-(4-trifluoromethylbenzyl)-4-hydroxymethylbenzylamine

Base Information

• Chemical Name: N-(tert-butoxycarbonyl)-N-(4-trifluoromethylbenzyl)-4-hydroxymethylbenzylamine
• CAS No.: 1276692-16-0
• Molecular Formula: C₂₁H₂₄F₃NO₃
• Molecular Weight: 395.422
• Mol file: 1276692-16-0.mol

Synonyms:N-(tert-butoxycarbonyl)-N-(4-trifluoromethylbenzyl)-4-hydroxymethylbenzylamine

Chemical Property of N-(tert-butoxycarbonyl)-N-(4-trifluoromethylbenzyl)-4-hydroxymethylbenzylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(tert-butoxycarbonyl)-N-(4-trifluoromethylbenzyl)-4-hydroxymethylbenzylamine

There total 5 articles about N-(tert-butoxycarbonyl)-N-(4-trifluoromethylbenzyl)-4-hydroxymethylbenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-(tert-butoxycarbonyl)-N-(4-trifluoromethylbenzyl)-4-(methylcarboxy)benzylamine (1276692-15-9) → N-(tert-butoxycarbonyl)-N-(4-trifluoromethylbenzyl)-4-hydroxymethylbenzylamine (1276692-16-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/ejoc.201001277

Reference yield:

N-(4-(methylcarboxy)benzylidene)-p-trifluoromethylbenzylamine (1276692-13-7) → N-(tert-butoxycarbonyl)-N-(4-trifluoromethylbenzyl)-4-hydroxymethylbenzylamine (1276692-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

2: dmap / dichloromethane / 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

With dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1002/ejoc.201001277

Reference yield:

p-Trifluoromethylbenzylamine (3300-51-4) → N-(tert-butoxycarbonyl)-N-(4-trifluoromethylbenzyl)-4-hydroxymethylbenzylamine (1276692-16-0)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene / Reflux

2: sodium tetrahydroborate / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

3: dmap / dichloromethane / 20 °C / Inert atmosphere

4: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

With dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; In tetrahydrofuran; methanol; dichloromethane; toluene;

DOI:10.1002/ejoc.201001277

upstream raw materials:

N-(4-(methylcarboxy)benzylidene)-p-trifluoromethylbenzylamine

N-(4-trifluoromethylbenzyl)-4-(methylcarboxy)benzylamine

N-(tert-butoxycarbonyl)-N-(4-trifluoromethylbenzyl)-4-(methylcarboxy)benzylamine

p-Trifluoromethylbenzylamine

Downstream raw materials:

N-(tert-butoxycarbonyl)-N-(4-trifluoromethylbenzyl)-4-bromobromomethylbenzylamine

α-[N-(tert-butoxycarbonyl)-4-trifluoromethylbenzylamino]-α'-(4-trifluoromethylbenzylamino)-p-xylene

α,α'-bis(4-trifluoromethylbenzylamino)-p-xylene