α-[N-(tert-butoxycarbonyl)-4-trifluoromethylbenzylamino]-α'-(4-trifluoromethylbenzylamino)-p-xylene

Base Information

• Chemical Name: α-[N-(tert-butoxycarbonyl)-4-trifluoromethylbenzylamino]-α'-(4-trifluoromethylbenzylamino)-p-xylene
• CAS No.: 1276692-18-2
• Molecular Formula: C₂₉H₃₀F₆N₂O₂
• Molecular Weight: 552.56
• Mol file: 1276692-18-2.mol

Synonyms:α-[N-(tert-butoxycarbonyl)-4-trifluoromethylbenzylamino]-α'-(4-trifluoromethylbenzylamino)-p-xylene

Chemical Property of α-[N-(tert-butoxycarbonyl)-4-trifluoromethylbenzylamino]-α'-(4-trifluoromethylbenzylamino)-p-xylene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-[N-(tert-butoxycarbonyl)-4-trifluoromethylbenzylamino]-α'-(4-trifluoromethylbenzylamino)-p-xylene

There total 7 articles about α-[N-(tert-butoxycarbonyl)-4-trifluoromethylbenzylamino]-α'-(4-trifluoromethylbenzylamino)-p-xylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

N-(tert-butoxycarbonyl)-N-(4-trifluoromethylbenzyl)-4-bromobromomethylbenzylamine (1276692-17-1) + p-Trifluoromethylbenzylamine (3300-51-4) → α-[N-(tert-butoxycarbonyl)-4-trifluoromethylbenzylamino]-α'-(4-trifluoromethylbenzylamino)-p-xylene (1276692-18-2)

Guidance literature:

In acetonitrile; for 3h; Reflux;

DOI:10.1002/ejoc.201001277

Reference yield:

N-(4-(methylcarboxy)benzylidene)-p-trifluoromethylbenzylamine (1276692-13-7) → α-[N-(tert-butoxycarbonyl)-4-trifluoromethylbenzylamino]-α'-(4-trifluoromethylbenzylamino)-p-xylene (1276692-18-2)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

2: dmap / dichloromethane / 20 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

4: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C

5: acetonitrile / 3 h / Reflux

With dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

DOI:10.1002/ejoc.201001277

Reference yield:

N-(tert-butoxycarbonyl)-N-(4-trifluoromethylbenzyl)-4-(methylcarboxy)benzylamine (1276692-15-9) → α-[N-(tert-butoxycarbonyl)-4-trifluoromethylbenzylamino]-α'-(4-trifluoromethylbenzylamino)-p-xylene (1276692-18-2)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C

2: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 20 °C

3: acetonitrile / 3 h / Reflux

With lithium aluminium tetrahydride; carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; acetonitrile;

DOI:10.1002/ejoc.201001277

upstream raw materials:

N-(4-(methylcarboxy)benzylidene)-p-trifluoromethylbenzylamine

N-(4-trifluoromethylbenzyl)-4-(methylcarboxy)benzylamine

N-(tert-butoxycarbonyl)-N-(4-trifluoromethylbenzyl)-4-(methylcarboxy)benzylamine

N-(tert-butoxycarbonyl)-N-(4-trifluoromethylbenzyl)-4-hydroxymethylbenzylamine

Downstream raw materials:

α,α'-bis(4-trifluoromethylbenzylamino)-p-xylene