(5-benzyl-pyridin-3-yl)-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol

Base Information

Chemical Name:(5-benzyl-pyridin-3-yl)-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol
CAS No.:1280733-24-5
Molecular Formula:C₂₃H₁₉BrN₂O₂
Molecular Weight:435.32
Hs Code.:

Synonyms:(5-benzyl-pyridin-3-yl)-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol

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Chemical Property of (5-benzyl-pyridin-3-yl)-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol

Chemical Property:

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Technology Process of (5-benzyl-pyridin-3-yl)-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol

There total 4 articles about (5-benzyl-pyridin-3-yl)-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 301220-81-5
3-benzyl-5-bromopyridine

: 1267684-96-7
5-(4-bromophenyl)-3-methylisoxazole-4-carbaldehyde

: 1068-55-9
isopropylmagnesium chloride

: 1280733-24-5
(5-benzyl-pyridin-3-yl)-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol

Guidance literature:: 3-benzyl-5-bromopyridine; isopropylmagnesium chloride; In tetrahydrofuran; at 0 - 20 ℃;

With n-butyllithium; In tetrahydrofuran; hexanes; at -78 - 0 ℃;

5-(4-bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde; In tetrahydrofuran; hexanes; at 0 - 20 ℃;

Reference yield:

: 85963-90-2
methyl 2-(4-bromobenzoyl)-3-oxo-butanoate

: 1280733-24-5
(5-benzyl-pyridin-3-yl)-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; acetic acid / 1 h / 115 °C

2.1: lithium borohydride; ethanol / 60 °C

3.1: 4-methylmorpholine N-oxide / tetrapropylammonium perruthennate / dichloromethane

4.1: tetrahydrofuran / 0 - 20 °C

4.2: -78 - 0 °C

4.3: 0 - 20 °C

With lithium borohydride; ethanol; hydroxylamine hydrochloride; acetic acid; 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1228689-61-9
methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate

: 1280733-24-5
(5-benzyl-pyridin-3-yl)-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium borohydride; ethanol / 60 °C

2.1: 4-methylmorpholine N-oxide / tetrapropylammonium perruthennate / dichloromethane

3.1: tetrahydrofuran / 0 - 20 °C

3.2: -78 - 0 °C

3.3: 0 - 20 °C

With lithium borohydride; ethanol; 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate; In tetrahydrofuran; dichloromethane;