2-(4-dimethylaminophenyl)-7-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

Base Information

Chemical Name:2-(4-dimethylaminophenyl)-7-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline
CAS No.:1374107-52-4
Molecular Formula:C₃₂H₃₆N₂O₆S
Molecular Weight:576.714
Hs Code.:

Synonyms:2-(4-dimethylaminophenyl)-7-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

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Chemical Property of 2-(4-dimethylaminophenyl)-7-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

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Technology Process of 2-(4-dimethylaminophenyl)-7-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

There total 10 articles about 2-(4-dimethylaminophenyl)-7-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1374107-51-3
2-(4-methylaminophenyl)-7-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

: 1374107-52-4
2-(4-dimethylaminophenyl)-7-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

Guidance literature:: With 2-picoline borane complex; acetic acid; In methanol; water; at 20 ℃; for 1.08333h; Cooling with ice;

Reference yield:

: 70500-72-0
quinoline-2,7-diol

: 1374107-52-4
2-(4-dimethylaminophenyl)-7-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

Guidance literature:: Multi-step reaction with 10 steps

1: thionyl chloride; N,N-dimethyl-formamide / 1 h / 20 - 70 °C / Cooling with ice

2: pyridinium p-toluenesulfonate / tetrahydrofuran / 16 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 8 h / 80 °C / Inert atmosphere

4: trifluoroacetic acid / chloroform / 2 h / 20 °C / Cooling with ice

5: triethylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

6: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 36 h / 20 °C / Cooling with ice

7: trifluoroacetic acid / chloroform; water / 8 h / 20 °C / Cooling with ice

8: toluene-4-sulfonic acid / tetrahydrofuran / 16 h / 20 °C

9: lithium hydroxide monohydrate; water / tetrahydrofuran / 0.5 h / 20 °C / Cooling with ice

10: acetic acid; 2-picoline borane complex / methanol; water / 1.08 h / 20 °C / Cooling with ice

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; 2-picoline borane complex; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; water; pyridinium p-toluenesulfonate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; chloroform; water;

Reference yield:

: 375358-19-3
2-chloroquinoline-7-ol

: 1374107-52-4
2-(4-dimethylaminophenyl)-7-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

Guidance literature:: Multi-step reaction with 9 steps

1: pyridinium p-toluenesulfonate / tetrahydrofuran / 16 h / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 8 h / 80 °C / Inert atmosphere

3: trifluoroacetic acid / chloroform / 2 h / 20 °C / Cooling with ice

4: triethylamine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 36 h / 20 °C / Cooling with ice

6: trifluoroacetic acid / chloroform; water / 8 h / 20 °C / Cooling with ice

7: toluene-4-sulfonic acid / tetrahydrofuran / 16 h / 20 °C

8: lithium hydroxide monohydrate; water / tetrahydrofuran / 0.5 h / 20 °C / Cooling with ice

9: acetic acid; 2-picoline borane complex / methanol; water / 1.08 h / 20 °C / Cooling with ice

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-picoline borane complex; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; water; pyridinium p-toluenesulfonate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; chloroform; water;