(8R,9R)-7,7-difluoro-2,3-dimethyl-8-hydroxy-9-phenyl-7H-8,9-dihydro-pyrano[2,3-c]imidazo[1,2-a]pyridine

Base Information

Chemical Name:(8R,9R)-7,7-difluoro-2,3-dimethyl-8-hydroxy-9-phenyl-7H-8,9-dihydro-pyrano[2,3-c]imidazo[1,2-a]pyridine
CAS No.:883229-34-3
Molecular Formula:C₁₈H₁₆F₂N₂O₂
Molecular Weight:330.334
Hs Code.:

Synonyms:(8R,9R)-7,7-difluoro-2,3-dimethyl-8-hydroxy-9-phenyl-7H-8,9-dihydro-pyrano[2,3-c]imidazo[1,2-a]pyridine

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Chemical Property of (8R,9R)-7,7-difluoro-2,3-dimethyl-8-hydroxy-9-phenyl-7H-8,9-dihydro-pyrano[2,3-c]imidazo[1,2-a]pyridine

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Technology Process of (8R,9R)-7,7-difluoro-2,3-dimethyl-8-hydroxy-9-phenyl-7H-8,9-dihydro-pyrano[2,3-c]imidazo[1,2-a]pyridine

There total 1 articles about (8R,9R)-7,7-difluoro-2,3-dimethyl-8-hydroxy-9-phenyl-7H-8,9-dihydro-pyrano[2,3-c]imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 362606-08-4
(8R,9R)-2,3-Dimethyl-8-hydroxy-9-phenyl-7H-8,9-dihydro-pyrano[2,3-c]imidazo[1,2-a]pyridin-7-one

: 883229-34-3
(8R,9R)-7,7-difluoro-2,3-dimethyl-8-hydroxy-9-phenyl-7H-8,9-dihydro-pyrano[2,3-c]imidazo[1,2-a]pyridine

Guidance literature:: With diethylamino-sulfur trifluoride; at -10 - 25 ℃; for 2.5h;

Reference yield: 78.0%

: 883229-34-3
(8R,9R)-7,7-difluoro-2,3-dimethyl-8-hydroxy-9-phenyl-7H-8,9-dihydro-pyrano[2,3-c]imidazo[1,2-a]pyridine

: 38870-89-2
Methoxyacetyl chloride

: (8R,9R)-7,7-difluoro-2,3-dimethyl-8-(2-methoxy-acetyloxy)-9-phenyl-7H-8,9-dihydro-pyrano[2,3-c]imidazo[1,2-a]pyridine

Guidance literature:: With triethylamine; dmap; In dichloromethane; at 25 ℃; for 1h;

Reference yield: 62.0%

: 883229-34-3
(8R,9R)-7,7-difluoro-2,3-dimethyl-8-hydroxy-9-phenyl-7H-8,9-dihydro-pyrano[2,3-c]imidazo[1,2-a]pyridine

: 1118-68-9
dimethylaminoacetic acid

: (8R,9R)-7,7-difluoro-2,3-dimethyl-8-(2-dimethylamino-acetyloxy)-9-phenyl-7H-8,9-dihydro-pyrano[2,3-c]imidazo[1,2-a]pyridine

Guidance literature:: dimethylaminoacetic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 45 ℃; for 2h;

(8R,9R)-7,7-difluoro-2,3-dimethyl-8-hydroxy-9-phenyl-7H-8,9-dihydro-pyrano[2,3-c]imidazo[1,2-a]pyridine; In tetrahydrofuran; at 25 ℃; for 4h;