2-Methyl-3-(4-{2-[5-methyl-2-cyclohexyl-oxazol-4-yl]-ethoxy}-phenyl)-2-phenoxypropionic Acid Ethyl Ester

Base Information

• Chemical Name: 2-Methyl-3-(4-{2-[5-methyl-2-cyclohexyl-oxazol-4-yl]-ethoxy}-phenyl)-2-phenoxypropionic Acid Ethyl Ester
• CAS No.: 401791-04-6
• Molecular Formula: C₃₀H₃₇NO₅
• Molecular Weight: 491.627

Synonyms:2-Methyl-3-(4-{2-[5-methyl-2-cyclohexyl-oxazol-4-yl]-ethoxy}-phenyl)-2-phenoxypropionic Acid Ethyl Ester

Chemical Property of 2-Methyl-3-(4-{2-[5-methyl-2-cyclohexyl-oxazol-4-yl]-ethoxy}-phenyl)-2-phenoxypropionic Acid Ethyl Ester

Chemical Property:

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Technology Process of 2-Methyl-3-(4-{2-[5-methyl-2-cyclohexyl-oxazol-4-yl]-ethoxy}-phenyl)-2-phenoxypropionic Acid Ethyl Ester

There total 7 articles about 2-Methyl-3-(4-{2-[5-methyl-2-cyclohexyl-oxazol-4-yl]-ethoxy}-phenyl)-2-phenoxypropionic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

Thien-3-ylboronic acid (6165-69-1) + 2-(3-Bromo-phenoxy)-3-{4-[2-(2-cyclohexyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-propionic Acid (401790-84-9) → 3-{4-[2-(2-Cyclohexyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-(3-thiophen-3-yl-phenoxy)-propionic Acid Ethyl Ester (401791-45-5) + 2-Methyl-3-(4-{2-[5-methyl-2-cyclohexyl-oxazol-4-yl]-ethoxy}-phenyl)-2-phenoxypropionic Acid Ethyl Ester (401791-04-6)

Guidance literature:

With potassium fluoride; triphenylphosphine; palladium diacetate; In tetrahydrofuran; acetone;

Reference yield: 28.0%

toluene-4-sulfonic acid 2-(2-cyclohexyk-5-methyloxazol-4-yl)ethyl ester (401791-03-5) + 3-(4-hydroxyphenyl)-2-methyl-2-phenoxypropionic acid ethyl ester (223126-69-0) → 2-Methyl-3-(4-{2-[5-methyl-2-cyclohexyl-oxazol-4-yl]-ethoxy}-phenyl)-2-phenoxypropionic Acid Ethyl Ester (401791-04-6)

Guidance literature:

With caesium carbonate; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

Thien-3-ylboronic acid (6165-69-1) + 2-(3-Bromo-phenoxy)-3-{4-[2-(2-cyclohexyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-propionic Acid (401790-84-9) → 2-(Biphenyl-3-yloxy)-3-{4-[2-(2-cyclohexyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-propionic Acid Ethyl Ester (401790-89-4) + 2-Methyl-3-(4-{2-[5-methyl-2-cyclohexyl-oxazol-4-yl]-ethoxy}-phenyl)-2-phenoxypropionic Acid Ethyl Ester (401791-04-6)

Guidance literature:

With potassium fluoride; triphenylphosphine; palladium diacetate; In tetrahydrofuran; acetone;

upstream raw materials:

toluene-4-sulfonic acid 2-(2-cyclohexyk-5-methyloxazol-4-yl)ethyl ester

3-(4-hydroxyphenyl)-2-methyl-2-phenoxypropionic acid ethyl ester

p-benzyloxybenzaldehyde

ethyl 2-phenoxypropionate

Downstream raw materials:

2-(3-Bromo-phenoxy)-3-{4-[2-(2-cyclohexyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-propionic Acid

3-{4-[2-(2-Cyclohexyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-(3-thiophen-3-yl-phenoxy)-propionic Acid

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