3,6-dichloro-pyridazine-4-carboxylic acid (2-hydroxy-4-trifluoromethyl-phenyl)-amide

Base Information

Chemical Name:3,6-dichloro-pyridazine-4-carboxylic acid (2-hydroxy-4-trifluoromethyl-phenyl)-amide
CAS No.:765303-32-0
Molecular Formula:C₁₂H₆Cl₂F₃N₃O₂
Molecular Weight:352.1
Hs Code.:

Synonyms:3,6-dichloro-pyridazine-4-carboxylic acid (2-hydroxy-4-trifluoromethyl-phenyl)-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,6-dichloro-pyridazine-4-carboxylic acid (2-hydroxy-4-trifluoromethyl-phenyl)-amide

Chemical Property:

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Technology Process of 3,6-dichloro-pyridazine-4-carboxylic acid (2-hydroxy-4-trifluoromethyl-phenyl)-amide

There total 1 articles about 3,6-dichloro-pyridazine-4-carboxylic acid (2-hydroxy-4-trifluoromethyl-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 454-82-0
2-hydroxy-4-(trifluoromethyl)aniline

: 6531-08-4
3,6-dichloropyridazine-5-carboxylic acid chloride

: 765303-32-0
3,6-dichloro-pyridazine-4-carboxylic acid (2-hydroxy-4-trifluoromethyl-phenyl)-amide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm040803n

Reference yield:

: 765303-32-0
3,6-dichloro-pyridazine-4-carboxylic acid (2-hydroxy-4-trifluoromethyl-phenyl)-amide

: 6-[3-(4-benzylpiperazin-1-yl)propyl]-3-chloro-9-trifluoromethylpyridazino[3,4-b][1,5]benzoxazepin-5(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / dioxane / Heating

2: 26 percent / Na₂CO₃; KI / dimethylformamide / 28 h / 60 - 90 °C

With sodium hydride; sodium carbonate; potassium iodide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm040803n

Reference yield:

: 765303-32-0
3,6-dichloro-pyridazine-4-carboxylic acid (2-hydroxy-4-trifluoromethyl-phenyl)-amide

: 3-chloro-9-trifluoromethyl-6-[3-(4-phenylpiperazin-1-yl)propyl]pyridazino[3,4-b][1,5]benzoxazepin-5(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / dioxane / Heating

2: 15 percent / KOH / acetone / 48 h

With potassium hydroxide; sodium hydride; In 1,4-dioxane; acetone;
DOI:10.1021/jm040803n