2-Amino-5-(trifluoromethyl)phenol

Base Information

Chemical Name:2-Amino-5-(trifluoromethyl)phenol
CAS No.:454-82-0
Molecular Formula:C7H6F3NO
Molecular Weight:177.126
Hs Code.:2922299090
UNII:ENX2MR5ALD
DSSTox Substance ID:DTXSID00573628
Nikkaji Number:J2.374.983A
Wikidata:Q82462407
Mol file:454-82-0.mol

Synonyms:2-Amino-5-(trifluoromethyl)phenol;454-82-0;2-Hydroxy-4-(trifluoromethyl)aniline;Phenol, 2-amino-5-(trifluoromethyl)-;2-Hydroxy 4-tfma;ENX2MR5ALD;MFCD08056279;Teriflunomide metabolite (2-hydroxy 4-tfma);4-Amino-3-hydroxybenzotrifluoride;UNII-ENX2MR5ALD;SCHEMBL1025296;2-Amino-5-trifluoromethylphenol;DTXSID00573628;2-Hydroxy-4-trifluoromethylaniline;2-hydroxy 4-trifluoromethyl aniline;AM9972;AKOS015890937;CK-0705;BL000195;SY239152;CS-0108762;EN300-121442;A826820;J-507890

Suppliers and Price of 2-Amino-5-(trifluoromethyl)phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Hydroxy-4-(trifluoromethyl)aniline
500mg
$ 105.00

TRC
2-Hydroxy-4-(trifluoromethyl)aniline
100mg
$ 45.00

SynQuest Laboratories
2-Hydroxy-4-(trifluoromethyl)aniline 97%
10 g
$ 594.00

SynQuest Laboratories
2-Hydroxy-4-(trifluoromethyl)aniline 97%
1 g
$ 72.00

SynQuest Laboratories
2-Hydroxy-4-(trifluoromethyl)aniline 97%
5 g
$ 306.00

Crysdot
2-Amino-5-(trifluoromethyl)phenol 95+%
5g
$ 238.00

Crysdot
2-Amino-5-(trifluoromethyl)phenol 95+%
10g
$ 416.00

Crysdot
2-Amino-5-(trifluoromethyl)phenol 95+%
25g
$ 832.00

Chemenu
2-Amino-5-(trifluoromethyl)phenol 95%
25g
$ 785.00

Chemenu
2-Amino-5-(trifluoromethyl)phenol 95%
10g
$ 393.00

Total 39 raw suppliers

Chemical Property of 2-Amino-5-(trifluoromethyl)phenol

Chemical Property:

Melting Point:>350 °C
Boiling Point:233.8 °C at 760 mmHg
PKA:8.75±0.10(Predicted)
Flash Point:95.2 °C
PSA：46.25000
Density:1.432 g/cm³
LogP:2.57440
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:177.04014830
Heavy Atom Count:12
Complexity:159

Purity/Quality:

97% ^*data from raw suppliers

2-Hydroxy-4-(trifluoromethyl)aniline ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1C(F)(F)F)O)N
Uses 2-Hydroxy-4-(trifluoromethyl)aniline, is a building block used in the synthesis of various chemical compounds, such as 2-Isobutyl-7-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine (I789265)

Technology Process of 2-Amino-5-(trifluoromethyl)phenol

There total 5 articles about 2-Amino-5-(trifluoromethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 402-17-5
2-nitro-5-trifluoromethylphenol

: 454-82-0
2-hydroxy-4-(trifluoromethyl)aniline

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 16h; Inert atmosphere;

Reference yield: 19.0%

: 75-63-8
Bromotrifluoromethane

: 95-55-6
2-amino-phenol

: 454-82-0
2-hydroxy-4-(trifluoromethyl)aniline

: 106877-48-9
2-amino-3-(trifluoromethyl)phenol

Guidance literature:: With α-picoline; sodium metabisulfite; sulfur dioxide; zinc; In N,N-dimethyl-formamide; at 65 ℃; for 2h; under 2250.2 - 3750.3 Torr;

Reference yield:

: 98-17-9
3-Trifluoromethylphenol

: 454-82-0
2-hydroxy-4-(trifluoromethyl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; nitric acid / 1 h / 20 - 40 °C

2: acetic acid; iron / water / 0.75 h / 135 °C

With nitric acid; iron; acetic acid; In water;
DOI:10.1016/j.ejmech.2012.08.016