2-HYDROXY-4-(TRIFLUOROMETHYL)ANILINE

Base Information

• Chemical Name: 2-HYDROXY-4-(TRIFLUOROMETHYL)ANILINE
• CAS No.: 454-82-0
• Molecular Formula: C7H6F3NO
• Molecular Weight: 177.126
• Hs Code.: 2922299090
• Mol file: 454-82-0.mol

Synonyms:2-Amino-5-(trifluoromethyl)phenol;

Chemical Property of 2-HYDROXY-4-(TRIFLUOROMETHYL)ANILINE

Chemical Property:

• Melting Point: >350 °C
• Boiling Point: 233.8 °C at 760 mmHg
• PKA: 8.75±0.10(Predicted)
• Flash Point: 95.2 °C
• PSA: 46.25000
• Density: 1.432 g/cm³
• LogP: 2.57440
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

2-Hydroxy-4-(trifluoromethyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Hydroxy-4-(trifluoromethyl)aniline, is a building block used in the synthesis of various chemical compounds, such as 2-Isobutyl-7-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine (I789265)

Technology Process of 2-HYDROXY-4-(TRIFLUOROMETHYL)ANILINE

There total 5 articles about 2-HYDROXY-4-(TRIFLUOROMETHYL)ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-nitro-5-trifluoromethylphenol (402-17-5) → 2-hydroxy-4-(trifluoromethyl)aniline (454-82-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 16h; Inert atmosphere;

Reference yield: 19.0%

Bromotrifluoromethane (75-63-8) + 2-amino-phenol (95-55-6) → 2-hydroxy-4-(trifluoromethyl)aniline (454-82-0) + 2-amino-3-(trifluoromethyl)phenol (106877-48-9)

Guidance literature:

With α-picoline; sodium metabisulfite; sulfur dioxide; zinc; In N,N-dimethyl-formamide; at 65 ℃; for 2h; under 2250.2 - 3750.3 Torr;

Reference yield:

3-Trifluoromethylphenol (98-17-9) → 2-hydroxy-4-(trifluoromethyl)aniline (454-82-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; nitric acid / 1 h / 20 - 40 °C

2: acetic acid; iron / water / 0.75 h / 135 °C

With nitric acid; iron; acetic acid; In water;

DOI:10.1016/j.ejmech.2012.08.016

upstream raw materials:

2-nitro-5-trifluoromethylphenol

Bromotrifluoromethane

2-amino-phenol

2-nitro-5-(trifluoromethyl)aniline

Downstream raw materials:

6-trifluoromethyl-quinolin-8-ol

7-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine

Refernces

• 1、 Kozic, Ján,Novotná, Eva,Volková, Marie,Stola?íková, Ji?ina,Trejtnar, Franti?ek,Wsól, Vladimír,Vin?ová, Jarmila. "Synthesis and in vitro antimycobacterial and isocitrate lyase inhibition properties of novel 2-methoxy-2′-hydroxybenzanilides, their thioxo analogues and benzoxazoles". . p. 108 - 119. Retrieved 2013/01/15.
• 2、 -. "HARMFUL ARTHROPOD CONTROL COMPOSITION, AND FUSED HETEROCYCLIC COMPOUND". Page/Page column 123. . Retrieved 2011/02/18.