tert-butyl 4-[2-(1-hydroxycyclohexyl)-2-(3-trifluoromethoxyphenyl)acetyl]piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[2-(1-hydroxycyclohexyl)-2-(3-trifluoromethoxyphenyl)acetyl]piperazine-1-carboxylate
CAS No.:850616-46-5
Molecular Formula:C₂₄H₃₃F₃N₂O₅
Molecular Weight:486.532
Hs Code.:

Synonyms:tert-butyl 4-[2-(1-hydroxycyclohexyl)-2-(3-trifluoromethoxyphenyl)acetyl]piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-[2-(1-hydroxycyclohexyl)-2-(3-trifluoromethoxyphenyl)acetyl]piperazine-1-carboxylate

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Technology Process of tert-butyl 4-[2-(1-hydroxycyclohexyl)-2-(3-trifluoromethoxyphenyl)acetyl]piperazine-1-carboxylate

There total 2 articles about tert-butyl 4-[2-(1-hydroxycyclohexyl)-2-(3-trifluoromethoxyphenyl)acetyl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 850563-08-5
(1-hydroxycyclohexyl)-(3-trifluoromethoxy)phenylacetic acid

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 850616-46-5
tert-butyl 4-[2-(1-hydroxycyclohexyl)-2-(3-trifluoromethoxyphenyl)acetyl]piperazine-1-carboxylate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 25 ℃; for 16h;
DOI:10.1021/jm8002262

Reference yield:

: 850616-46-5
tert-butyl 4-[2-(1-hydroxycyclohexyl)-2-(3-trifluoromethoxyphenyl)acetyl]piperazine-1-carboxylate

Guidance literature:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 850616-46-5
tert-butyl 4-[2-(1-hydroxycyclohexyl)-2-(3-trifluoromethoxyphenyl)acetyl]piperazine-1-carboxylate

: 850616-48-7
1-{2-(4-methylpiperazin-1-yl)-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol

Guidance literature:: formaldehyd; tert-butyl 4-[2-(1-hydroxycyclohexyl)-2-(3-trifluoromethoxyphenyl)acetyl]piperazine-1-carboxylate; With formic acid; In water; at 50 - 70 ℃; for 1.5h;

With sodium hydroxide; In water; pH=10;