(E)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(4-hydroxy-3-methoxy-phenyl)-propenone

Base Information

• Chemical Name: (E)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(4-hydroxy-3-methoxy-phenyl)-propenone
• CAS No.: 224578-05-6
• Molecular Formula: C₂₀H₂₅NO₅S
• Molecular Weight: 391.488
• Mol file: 224578-05-6.mol

Synonyms:(E)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(4-hydroxy-3-methoxy-phenyl)-propenone

Chemical Property of (E)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(4-hydroxy-3-methoxy-phenyl)-propenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(4-hydroxy-3-methoxy-phenyl)-propenone

There total 5 articles about (E)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(4-hydroxy-3-methoxy-phenyl)-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Acetic acid 4-[(E)-3-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-3-oxo-propenyl]-2-methoxy-phenyl ester (224578-11-4) → (E)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-3-(4-hydroxy-3-methoxy-phenyl)-propenone (224578-05-6)

Guidance literature:

With sodium methylate; In methanol;

DOI:10.1055/s-1999-2595

Reference yield:

4-acetoxy-3-methoxycinnamoyl chloride (50906-12-2) → (E)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-3-(4-hydroxy-3-methoxy-phenyl)-propenone (224578-05-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / toluene / 2 h / 20 °C

2: 0.52 g / CH₃ONa / methanol / 0.5 h

With sodium methylate; sodium hydride; In methanol; toluene;

DOI:10.1016/S0040-4020(00)00944-3

Reference yield:

(+)-camphorsultam (108448-77-7,124224-04-0) → (E)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-3-(4-hydroxy-3-methoxy-phenyl)-propenone (224578-05-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / toluene / 2 h / 20 °C

2: 0.52 g / CH₃ONa / methanol / 0.5 h

With sodium methylate; sodium hydride; In methanol; toluene;

DOI:10.1016/S0040-4020(00)00944-3

upstream raw materials:

Acetic acid 4-[(E)-3-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-oxo-propenyl]-2-methoxy-phenyl ester

4-acetoxy-3-methoxycinnamoyl chloride

(+)-camphorsultam

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid