methyl [4-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-piperidin-1-ylpropyl)amino]methyl}phenyl]acetate hydrobromide

Base Information

Chemical Name:methyl [4-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-piperidin-1-ylpropyl)amino]methyl}phenyl]acetate hydrobromide
CAS No.:1381766-58-0
Molecular Formula:BrH*C₃₀H₄₅N₇O₄
Molecular Weight:648.644
Hs Code.:

Synonyms:methyl [4-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-piperidin-1-ylpropyl)amino]methyl}phenyl]acetate hydrobromide

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Chemical Property of methyl [4-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-piperidin-1-ylpropyl)amino]methyl}phenyl]acetate hydrobromide

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Technology Process of methyl [4-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-piperidin-1-ylpropyl)amino]methyl}phenyl]acetate hydrobromide

There total 11 articles about methyl [4-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-piperidin-1-ylpropyl)amino]methyl}phenyl]acetate hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1381766-54-6
methyl [4-({[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl][3-(piperidin-1-yl)propyl]amino}methyl)phenyl]acetate

: 1381766-58-0
methyl [4-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-piperidin-1-ylpropyl)amino]methyl}phenyl]acetate hydrobromide

Guidance literature:: methyl [4-({[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl][3-(piperidin-1-yl)propyl]amino}methyl)phenyl]acetate; With hydrogen bromide; In methanol; at 20 ℃; for 1h;

With methanol; In tert-butyl methyl ether; at 20 ℃; for 96h;

Reference yield:

: 7398-42-7
methyl 2-(4-(bromomethyl)phenyl)acetate

: 1381766-58-0
methyl [4-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-piperidin-1-ylpropyl)amino]methyl}phenyl]acetate hydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methylmorpholine N-oxide / toluene; acetonitrile / 5 h / 0 - 20 °C

1.2: activated charcoal

2.1: triethylamine / 1-methyl-pyrrolidin-2-one / 0.5 h / 25 °C

2.2: 0.25 h

2.3: 8 h

3.1: lithium bromide / acetone / 2 h / 50 °C

3.2: 1.42 h / 10 - 18 °C

4.1: hydrogen bromide / methanol / 1 h / 20 °C

4.2: 96 h / 20 °C

With hydrogen bromide; 4-methylmorpholine N-oxide; triethylamine; lithium bromide; In 1-methyl-pyrrolidin-2-one; methanol; acetone; toluene; acetonitrile;

Reference yield:

: 96524-70-8
methyl 2-(4-formylphenyl)acetate

: 1381766-58-0
methyl [4-{[[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl](3-piperidin-1-ylpropyl)amino]methyl}phenyl]acetate hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / 1-methyl-pyrrolidin-2-one / 0.5 h / 25 °C

1.2: 0.25 h

1.3: 8 h

2.1: lithium bromide / acetone / 2 h / 50 °C

2.2: 1.42 h / 10 - 18 °C

3.1: hydrogen bromide / methanol / 1 h / 20 °C

3.2: 96 h / 20 °C

With hydrogen bromide; triethylamine; lithium bromide; In 1-methyl-pyrrolidin-2-one; methanol; acetone;