7398-42-7

Basic information

• Product Name: 4-(Bromomethyl)phenylaceticacidphenacylester
• Synonyms: Benzeneacetic acid, 4-(bromomethyl)-, methyl ester;Methyl4-(bromomethyl)phenylacetate98%;Methyl 2-(4-(bromomethyl);4-(Bromomethyl)benzeneacetic acid phenacyl ester;p-(Bromomethyl)phenylacetic acid phenacyl ester;Phenacyl=p-(bromomethyl)phenylacetate;Methyl 4-(bromomethyl)phenylacetate 98%;Methyl 2-(4-(broMoMethyl)phenyl)acetate
• CAS NO: 7398-42-7
• Molecular Formula: C₁₀H₁₁BrO₂
• Molecular Weight: 243.11
• Mol File: 7398-42-7.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 290.6±20.0 °C(Predicted)
• Appearance: /
• Density: 1.415±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 4-(Bromomethyl)phenylaceticacidphenacylester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Bromomethyl)phenylaceticacidphenacylester(7398-42-7)
• EPA Substance Registry System: 4-(Bromomethyl)phenylaceticacidphenacylester(7398-42-7)

Safety Data

• Hazardous Substances Data: 7398-42-7(Hazardous Substances Data)

Usage

General Description

4-(Bromomethyl)phenylacetic acid phenacylester is a chemical compound with the molecular formula C17H15BrO3. It is a derivative of phenylacetic acid and is commonly used in organic synthesis. The compound contains a bromomethyl group and a phenacylester group, which makes it suitable for various chemical reactions and transformations. It is widely used in pharmaceutical and agrochemical industries for the synthesis of various biologically active compounds. The chemical is known for its reactivity and versatility in different chemical reactions, making it an important building block in organic synthesis.

Upstream product

• 34472-65-6 (trimethylsilyl)diazomethane 
• 13737-36-5 4-bromophenylacetic acid 
• 75-77-4 chloro-trimethyl-silane 
• 622-47-9 4-tolylacetic acid 
• 67-56-1 methanol 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 23786-13-2 methyl p-tolylacetate 

Downstream Products

• 455323-54-3 N-(dicyclohexyl)acetyl-4-[4-(methoxycarbonylmethyl)benzylidene]piperidine 
• 808753-05-1 (4-methylaminomethyl-phenyl)-acetic acid methyl ester 
• 369654-63-7 methyl 4-(N-2-picolylamino methyl) phenyl acetate 
• 923565-72-4 1,1-dimethylethyl (2S)-2-methyl-4-((4-(2-(methyloxy)-2-oxoethyl)phenyl)methyl)-1-piperazinecarboxylate 
• 923565-76-8 phenylmethyl (2R)-2-methyl-4-((4-(2-(methyloxy)-2-oxoethyl)phenyl)methyl)-1-piperazinecarboxylate 
• 155380-12-4 [4-(2-ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenyl]-acetic acid methyl ester 
• 1246383-34-5 {4-[3-chloro-4-(3,3,3-trifluoro-2-hydroxy-2-isoquinolin-5-yl-1-methyl-propyl)-phenoxymethyl]-phenyl}-acetic acid methyl ester 
• 1417220-86-0 methyl 2-diazo-2-(4-((dimethylamino)methyl)phenyl)acetate 
• 1417220-99-5 methyl 2-(4-((4-(2-(2-(2-(2-(4-(prop-2-yn-1-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)phenyl)acetate 
• 1417220-90-6 methyl 2-diazo-2-(4-((4-(2-(2-(2-(2-(4-(prop-2-yn-1-yl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)methyl)phenyl)acetate 
• 808753-10-8 [4-(2-cyano-vinyl)-phenyl]-acetic acid methyl ester 

Relevant articles and documents

Preparation method of 4-bromomethyl methyl benzoate and derivative thereof

The invention provides a preparation method of methyl 4-bromomethyl benzoate and a derivative thereof, and the method comprises an esterification reaction for converting methyl benzoic acid into methyl benzoate and a bromination reaction for converting the methyl benzoate into the methyl 4-bromomethyl benzoate and the derivative thereof, the brominating agent for the bromination reaction is dibromohydantoin, and the structural formulas of the 4-bromomethyl methyl benzoate and the derivatives thereof are shown in the specification, wherein n1 is equal to 0, 1 or 2; n2 is equal to 1 or 2; according to the preparation method disclosed by the invention, the reaction time can be greatly shortened, the reaction yield is high, and the production efficiency is improved.

Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity

Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme involved in the recycling of nicotinamide to maintain adequate NAD levels inside the cells. It has been postulated to be a pharmacological target, as it is overexpressed in cancer cells as well as in inflammatory diseases. We describe the synthesis and characterization of a novel class of one-digit nanomolar NAMPT inhibitors based on in vitro characterization. The most active compound tested, 30c, displayed activity in xenograft and allograft models, strengthening the potential of NAMPT inhibitors as antitumoral drugs. Furthermore, in the present contribution we describe the ability of 30c to significantly improve the outcome of colitis in mice. Given that this is the first report of an effect of NAMPT inhibitors in colitis, this result paves the way for novel applications for this class of compounds.

PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF

Provided herein are compounds of formula (I) useful for the treatment of PPAR-delta related diseases (e.g. mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases).