N-[(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]-2-methoxyacetamide

Base Information

Chemical Name:N-[(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]-2-methoxyacetamide
CAS No.:1613639-60-3
Molecular Formula:C₁₆H₁₈BrN₃O₂
Molecular Weight:364.242
Hs Code.:

Synonyms:N-[(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]-2-methoxyacetamide

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Chemical Property of N-[(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]-2-methoxyacetamide

Chemical Property:

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Technology Process of N-[(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]-2-methoxyacetamide

There total 5 articles about N-[(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]-2-methoxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613639-55-6
(R)-N-(5-bromopyridin-3-yl)-1-phenylethane-1,2-diamine

: 625-45-6
2-methoxyacetic acid

: 1613639-60-3
N-[(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]-2-methoxyacetamide

Guidance literature:: With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 875-74-1
(R)-phenylglycine

: 1613639-60-3
N-[(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]-2-methoxyacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: L-proline; potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: hydrazine hydrate / ethanol / 1 h / 80 °C / Inert atmosphere

4: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; hydrazine hydrate; triethylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; L-proline; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 2: |Mitsunobu Displacement;

Reference yield:

: 625-92-3
3,5-dibromopyridine

: 1613639-60-3
N-[(R)-2-(5-bromopyridin-3-ylamino)-2-phenylethyl]-2-methoxyacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: L-proline; potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 12 h / 100 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: hydrazine hydrate / ethanol / 1 h / 80 °C / Inert atmosphere

4: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; hydrazine hydrate; triethylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; L-proline; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; 2: |Mitsunobu Displacement;