methyl-(2-{methyl-[4-prop-2-ynylcarbamoyl-2,6-bis-(quinolin-6-ylcarbamoyloxymethyl)-phenoxycarbonyl]-amino}-ethyl)-carbamic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester

Base Information

• Chemical Name: methyl-(2-{methyl-[4-prop-2-ynylcarbamoyl-2,6-bis-(quinolin-6-ylcarbamoyloxymethyl)-phenoxycarbonyl]-amino}-ethyl)-carbamic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester
• CAS No.: 929535-89-7
• Molecular Formula: C₆₀H₆₈N₁₀O₁₅
• Molecular Weight: 1169.26
• Mol file: 929535-89-7.mol

Synonyms:methyl-(2-{methyl-[4-prop-2-ynylcarbamoyl-2,6-bis-(quinolin-6-ylcarbamoyloxymethyl)-phenoxycarbonyl]-amino}-ethyl)-carbamic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester

Chemical Property of methyl-(2-{methyl-[4-prop-2-ynylcarbamoyl-2,6-bis-(quinolin-6-ylcarbamoyloxymethyl)-phenoxycarbonyl]-amino}-ethyl)-carbamic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl-(2-{methyl-[4-prop-2-ynylcarbamoyl-2,6-bis-(quinolin-6-ylcarbamoyloxymethyl)-phenoxycarbonyl]-amino}-ethyl)-carbamic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester

There total 13 articles about methyl-(2-{methyl-[4-prop-2-ynylcarbamoyl-2,6-bis-(quinolin-6-ylcarbamoyloxymethyl)-phenoxycarbonyl]-amino}-ethyl)-carbamic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-hydroxy-3,5-bis(hydroxymethyl)-N-(prop-2-ynyl)benzamide (916084-84-9) → methyl-(2-{methyl-[4-prop-2-ynylcarbamoyl-2,6-bis-(quinolin-6-ylcarbamoyloxymethyl)-phenoxycarbonyl]-amino}-ethyl)-carbamic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester (929535-89-7)

Guidance literature:

Multi-step reaction with 8 steps

1: 80 percent / imidazole / dimethylformamide / 2 h / 20 °C

2: 90 percent / NEt₃ / tetrahydrofuran / 1 h / 20 °C

3: 90 percent / dimethylformamide / 1 h / 20 °C

4: 56 percent / amberlyst-15 / methanol / 2 h / 20 °C

5: 82 percent / N,N-diisopropyl ethylamine; pyridine / tetrahydrofuran / 0 - 20 °C

6: 62 percent / 1-hydroxybenzotriazole; N,N-diisopropyl ethylamine / dimethylformamide / 50 °C

7: 131 mg / NEt₃ / dimethylformamide

With pyridine; 1H-imidazole; amberlyst-15; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1002/chem.200601263

Reference yield:

{2-[(2-tert-butoxycarbonylamino-ethyl)-(4-hydroxymethyl-phenoxycarbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester (929535-87-5) → methyl-(2-{methyl-[4-prop-2-ynylcarbamoyl-2,6-bis-(quinolin-6-ylcarbamoyloxymethyl)-phenoxycarbonyl]-amino}-ethyl)-carbamic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester (929535-89-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / N,N-diisopropyl ethylamine; pyridine / tetrahydrofuran / 1 h / 20 °C

2: 131 mg / NEt₃ / dimethylformamide

With pyridine; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/chem.200601263

Reference yield:

{2-[(2,6-bis-hydroxymethyl-4-prop-2-ynylcarbamoyl-phenoxycarbonyl)-methyl-amino]-ethyl}-methyl-carbamic acid tert-butyl ester (916084-88-3) → methyl-(2-{methyl-[4-prop-2-ynylcarbamoyl-2,6-bis-(quinolin-6-ylcarbamoyloxymethyl)-phenoxycarbonyl]-amino}-ethyl)-carbamic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester (929535-89-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / N,N-diisopropyl ethylamine; pyridine / tetrahydrofuran / 0 - 20 °C

2: 62 percent / 1-hydroxybenzotriazole; N,N-diisopropyl ethylamine / dimethylformamide / 50 °C

3: 131 mg / NEt₃ / dimethylformamide

With pyridine; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/chem.200601263

upstream raw materials:

carbonic acid 4-[bis-(2-tert-butoxycarbonylamino-ethyl)-carbamoyloxy]-benzyl ester 4-nitro-phenyl ester

4-hydroxy-3,5-bis(hydroxymethyl)-N-(prop-2-ynyl)benzamide

{2-[(2-tert-butoxycarbonylamino-ethyl)-(4-hydroxymethyl-phenoxycarbonyl)-amino]-ethyl}-carbamic acid tert-butyl ester

3,5-bis((tert-butyldimethylsilyloxy)methyl)-4-hydroxy-N-(prop-2-ynyl)benzamide