ethyl 3-((2-chloro-5-nitropyrimidin-4-yl)(cyclohexyl)amino)-2-fluoro-2-methylpropanoate

Base Information

Chemical Name:ethyl 3-((2-chloro-5-nitropyrimidin-4-yl)(cyclohexyl)amino)-2-fluoro-2-methylpropanoate
CAS No.:1137869-69-2
Molecular Formula:C₁₆H₂₂ClFN₄O₄
Molecular Weight:388.826
Hs Code.:

Synonyms:ethyl 3-((2-chloro-5-nitropyrimidin-4-yl)(cyclohexyl)amino)-2-fluoro-2-methylpropanoate

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Chemical Property of ethyl 3-((2-chloro-5-nitropyrimidin-4-yl)(cyclohexyl)amino)-2-fluoro-2-methylpropanoate

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Technology Process of ethyl 3-((2-chloro-5-nitropyrimidin-4-yl)(cyclohexyl)amino)-2-fluoro-2-methylpropanoate

There total 1 articles about ethyl 3-((2-chloro-5-nitropyrimidin-4-yl)(cyclohexyl)amino)-2-fluoro-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1137869-68-1
ethyl 3-(cyclohexylamino)-2-fluoro-2-methylpropanoate

: 49845-33-2
2,4-Dichloro-5-nitropyrimidine

: 1137869-69-2
ethyl 3-((2-chloro-5-nitropyrimidin-4-yl)(cyclohexyl)amino)-2-fluoro-2-methylpropanoate

Guidance literature:: ethyl 3-(cyclohexylamino)-2-fluoro-2-methylpropanoate; 2,4-Dichloro-5-nitropyrimidine; In acetone; at 0 ℃; for 0.166667h;

With potassium carbonate; In acetone; at 20 ℃; for 18h;

Reference yield: 52.0%

: 1137869-69-2
ethyl 3-((2-chloro-5-nitropyrimidin-4-yl)(cyclohexyl)amino)-2-fluoro-2-methylpropanoate

: 1137869-70-5
2-chloro-9-cyclohexyl-7-fluoro-7-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one

Guidance literature:: ethyl 3-((2-chloro-5-nitropyrimidin-4-yl)(cyclohexyl)amino)-2-fluoro-2-methylpropanoate; With hydrogenchloride; iron; acetic acid; In water; at 0 - 60 ℃; for 18h;

With sodium hydroxide; water; In ethyl acetate; at 0 ℃;