49845-33-2Relevant articles and documents
Solid-phase synthesis of N-9-substituted 2,8-diaminopurines
Cole, Andrew G.,Metzger, Axel,Ahmed, Gulzar,Brescia, Marc-Raleigh,Chan, Ray J.,Wen, James,O'Brien, Linda,Qin, Lan-Ying,Henderson, Ian
, p. 8897 - 8900 (2006)
A general and efficient solid-phase synthesis of N-9-substituted 2,8-diaminopurines from 5-nitrouracil is described. The key synthetic transformation employs a carbodiimide-mediated cyclization of a thiourea. Thiourea formation on solid phase is performed
Method for preparing 2, 4 - dichloro -5 - nitropyrimidine
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Paragraph 0017; 0020-0032, (2021/09/08)
The invention discloses a method for preparing 2, 4 - dichloro -5 - nitropyrimidine, wherein, 5 - nitro uracil is put into a reactor, and the reaction is stopped when the product content 50 °C 95% or more is increased to 100 °C dropwise DMF. The dichloroethane layer was removed by filtration, and the 2 mixture 4 -dichloro -5 -nitropyrimidine was distilled off under reduced pressure. The reaction conditions are easy to control, operation is simple, yield is high, production cost is low, safety and environmental protection are achieved, and industrial production can be realized.
Efficient Phosphorus-Free Chlorination of Hydroxy Aza-Arenes and Their Application in One-Pot Pharmaceutical Synthesis
Wang, Jian,Li, Yan-Hui,Pan, Song-Cheng,Li, Ming-Fang,Du, Wenting,Yin, Hong,Li, Jing-Hua
supporting information, p. 146 - 153 (2020/03/10)
The chlorination of hydroxy aza-arenes with bis(trichloromethyl) carbonate (BTC) and SOCl2 has been effectively performed by refluxing with 5 wt % 4-dimethylaminopyridine (DMAP) as a catalyst. Various substrates are chlorinated with high yields. The obtained chlorinated aza-arenes can be used directly with simple workup for succedent one-pot synthesis on a large scale.