dimethyl 7'-((4-((4-(acetylthio)phenyl)ethynyl)phenyl)ethynyl)-8a'H-spiro[fluorene-9,1'-indolizine]-2',3'-dicarboxylate

Base Information

Chemical Name:dimethyl 7'-((4-((4-(acetylthio)phenyl)ethynyl)phenyl)ethynyl)-8a'H-spiro[fluorene-9,1'-indolizine]-2',3'-dicarboxylate
CAS No.:1262327-52-5
Molecular Formula:C₄₂H₂₉NO₅S
Molecular Weight:659.762
Hs Code.:

Synonyms:dimethyl 7'-((4-((4-(acetylthio)phenyl)ethynyl)phenyl)ethynyl)-8a'H-spiro[fluorene-9,1'-indolizine]-2',3'-dicarboxylate

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Chemical Property of dimethyl 7'-((4-((4-(acetylthio)phenyl)ethynyl)phenyl)ethynyl)-8a'H-spiro[fluorene-9,1'-indolizine]-2',3'-dicarboxylate

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Technology Process of dimethyl 7'-((4-((4-(acetylthio)phenyl)ethynyl)phenyl)ethynyl)-8a'H-spiro[fluorene-9,1'-indolizine]-2',3'-dicarboxylate

There total 12 articles about dimethyl 7'-((4-((4-(acetylthio)phenyl)ethynyl)phenyl)ethynyl)-8a'H-spiro[fluorene-9,1'-indolizine]-2',3'-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 39500-48-6
spiro[2-cyclopropene-1,9'-fluorene]-2,3-dimethyldicarboxylate

: 1073675-34-9
1-((4-acetylthiophenyl)ethynyl)-4-((4-pyridyl)ethynyl)benzene

: 1262327-52-5
dimethyl 7'-((4-((4-(acetylthio)phenyl)ethynyl)phenyl)ethynyl)-8a'H-spiro[fluorene-9,1'-indolizine]-2',3'-dicarboxylate

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 15h; Inert atmosphere; Darkness;
DOI:10.1016/j.tetlet.2010.10.097

Reference yield:

: 2510-22-7
4-pyridylacetylene

: 1262327-52-5
dimethyl 7'-((4-((4-(acetylthio)phenyl)ethynyl)phenyl)ethynyl)-8a'H-spiro[fluorene-9,1'-indolizine]-2',3'-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 13 h / 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 48 h / 40 °C / Inert atmosphere

3: potassium hydroxide / methanol / 2 h / 20 °C / Inert atmosphere

4: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

5: tetrahydrofuran / 15 h / 20 °C / Inert atmosphere; Darkness

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; 1: Sonogashira coupling / 2: Sonogashira coupling / 4: Sonogashira coupling;
DOI:10.1016/j.tetlet.2010.10.097

Reference yield:

: 4-((4-((trimethylsilyl)ethynyl)phenyl)ethynyl)pyridine

: 1262327-52-5
dimethyl 7'-((4-((4-(acetylthio)phenyl)ethynyl)phenyl)ethynyl)-8a'H-spiro[fluorene-9,1'-indolizine]-2',3'-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / methanol / 2 h / 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

3: tetrahydrofuran / 15 h / 20 °C / Inert atmosphere; Darkness

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; potassium hydroxide; In tetrahydrofuran; methanol; 2: Sonogashira coupling;
DOI:10.1016/j.tetlet.2010.10.097