4-Ethynylpyridine

Base Information

• Chemical Name: 4-Ethynylpyridine
• CAS No.: 2510-22-7
• Molecular Formula: C7H5 N
• Molecular Weight: 103.123
• Hs Code.: 2933399090
• Mol file: 2510-22-7.mol

Synonyms:(Pyridin-4-yl)acetylene;4-Ethynylpyridine; 4-Pyridylacetylene; 4-Pyridylethyne

Chemical Property of 4-Ethynylpyridine

Chemical Property:

• Vapor Pressure: 1.94mmHg at 25°C
• Melting Point: 98 °C
• Boiling Point: 170.5oC at 760 mmHg
• PKA: 4.16±0.10(Predicted)
• Flash Point: 57.5oC
• PSA: 12.89000
• Density: 1.02g/cm3
• LogP: 1.06290
• Storage Temp.: Freezer
• Solubility.: almost transparency in Acetone

Purity/Quality:

97% ^*data from raw suppliers

4-Ethynylpyridine >98.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Ethynylpyridine

There total 26 articles about 4-Ethynylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-(2-(trimethylsilyl)ethynyl)pyridine (133810-35-2) → 4-pyridylacetylene (2510-22-7)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.cgd.8b01140

Reference yield: 90.0%

2-methyl-4-(pyridin-4-yl)but-3-yn-2-ol (55384-91-3) → 4-pyridylacetylene (2510-22-7)

Guidance literature:

With sodium hydroxide; In toluene; for 2h; Heating;

Reference yield: 88.0%

4-(1′-bromoethenyl)pyridine (241481-87-8) → 4-pyridylacetylene (2510-22-7)

Guidance literature:

With sodium amide; In diethyl ether; ammonia; at -78 - -30 ℃; 2 h, reflux;

DOI:10.1016/S0040-4039(99)01019-9

upstream raw materials:

2-methyl-4-(pyridin-4-yl)but-3-yn-2-ol

4-bromopyridin

trimethylsilylacetylene

1,1,3,3-tetraphenyl-1-propene

Downstream raw materials:

1,1,3,3-tetraphenyl-1-propene

6-Chloro-4-cyclopropyl-1-(4-methoxy-benzyl)-4-pyridin-4-ylethynyl-3,4-dihydro-1H-quinazolin-2-one

1,2-bis(4-pyridyl)ethyne

1,4-bis(pyridine-4-ylethynyl)benzene

Refernces

New rhodium(I) supramolecular structures containing pyridyl and bipyridyl ligands

10.1016/j.jorganchem.2009.08.014

The research explores the self-assembly of rhodium(I) metallosupramolecular structures using [RhCl(CO)2]2 as an acceptor unit. Key chemicals involved in the research include [RhCl(CO)2]2, alkynylgold complex [Au(C?CC5H4N)(CNC6H4O(O)CC6H4OC10H21)], 4-ethynylpyridine, 4,4'-bipyridine, and diphosphines such as 1,4-bis(diphenylphosphino)butane (dppb) and 1,1-bis-(diphenylphosphino)methane (dppm). The study investigates the formation of various rhodium complexes through reactions with these chemicals, resulting in the creation of mono-, bi-, and three-dimensional structures. Notably, an unexpected isonitrile transfer from gold to rhodium centers was observed, and the influence of diphosphine bite angles on the final product structures was demonstrated. The research also includes the use of PM3 semi-empirical methods to optimize the geometry of the synthesized compounds, particularly focusing on the potential applications of these structures in catalysis and molecular recognition.